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HA-1004

Catalog No. T27525 CAS 91742-10-8

HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.

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HA-1004, CAS 91742-10-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 437.00
10 mg	In stock	$ 646.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,860.00
500 mg	In stock	$ 3,720.00

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Purity: 99.03%

Purity: 98.91%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.
In vitro	HA-100 inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively [2].

Molecular Weight	293.34
Formula	C12H15N5O2S
CAS No.	91742-10-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (37.5 mM)

References and Literature

1. Junying Yu, et al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557. 2. M Hagiwara, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. 3. P Almela, et al. Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. J Pharmacol Exp Ther. 2009 Sep;330(3):771-82. 4. Franz Varga, et al. Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts. Endocr J. 2009;56(3):441-50.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library TGF-beta/Smad Compound Library Kinase Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library Metabolism Compound Library ReFRAME Related Library Epigenetics Compound Library Cytoskeletal Signaling Pathway Compound Library

Related Products

Related compounds with same targets

Chymotrypsin SGC-GAK-1 SRPKIN-1 Wortmannin Benzamidine hydrochloride GAK inhibitor 49 IPR-803 Cetraxate hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HA-1004 91742-10-8 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling Metabolism Tyrosine Kinase/Adaptors PKC PKA Serine/threonin kinase HA 1004 HA1004 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.