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Ipratropium Bromide

Catalog No. T6547   CAS 22254-24-6
Synonyms: Sch 1000, Itrop, Atrovent

Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.

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Ipratropium Bromide Chemical Structure
Ipratropium Bromide, CAS 22254-24-6
Pack Size Availability Price/USD Quantity
50 mg In stock $ 38.00
100 mg In stock $ 48.00
200 mg In stock $ 82.00
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Purity: 99.94%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.
In vitro Ipratropium bromide combined with Formoterol partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity. [1] Ipratropium bromide (1 nM) significantly increases [Ca(2+)](i), decreases forward scatter and increases annexin-V-binding. Ipratropium bromide treatment is followed by slight but significant increase of hemolysis. Ipratropium bromide triggers suicidal erythrocyte death or eryptosis, an effect mainly due to stimulation of Ca(2+)-entry. [2]
In vivo Ipratropium dry powder inhalation (DPI) at a dose of 2400 mg/horse is an effective bronchodilator in these horses at rest but it has little effect on the airway calibre during the recovery period. [3] Ipratropium significantly attenuates the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium treated rats. Ipratropium bromide partially protects the lungs against the inflammation by reducing neutrophilic infiltration. [4] Ipratropium is an antagonist for pre-junctional muscarinic inhibitory receptors on pulmonary parasympathetic nerves and also confirms its potent antagonist actions on post-junctional muscarinic receptors in the airway smooth muscle in the guinea-pig. [5] Ipratropium decreases the maximal change in pleural pressure during tidal breathing (delta Pplmax) and pulmonary resistance (RL) and increases dynamic compliance (Cdyn) in horse. [6]
Synonyms Sch 1000, Itrop, Atrovent
Molecular Weight 412.37
Formula C20H30BrNO3
CAS No. 22254-24-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 201.3 mM

DMSO: 201.3 mM

TargetMolReferences and Literature

1. Zhang W, et al. Eur J Pharmacol,2010, 647(1-3), 178-187. 2. Shaik N, et al. Cell Physiol Biochem,2012, 30(6), 1517-1525. 3. Duvivier DH, et al. Equine Vet J,1999, 31(1), 20-24. 4. Zhang W, et al. Eur J Pharmacol,2010, 628(1-3), 171-178. 5. Fryer AD, et al. Eur J Pharmacol,1987, 139(2), 187-191.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Inhibitor Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library GPCR Compound Library Human Metabolite Library

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Keywords

Ipratropium Bromide 22254-24-6 Neuroscience AChR Ipratropium asthma chronic obstructive pulmonary disease Sch 1000 inhibit Inhibitor Sch-1000 Sch1000 Itrop mAChR Muscarinic acetylcholine receptor ischaemia/reperfusion I/R Atrovent inhibitor

 

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