Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 90.00 | |
5 mg | In stock | $ 185.00 | |
10 mg | In stock | $ 265.00 | |
25 mg | In stock | $ 477.00 | |
50 mg | In stock | $ 681.00 | |
100 mg | In stock | $ 970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 212.00 |
Description | NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19). |
In vivo | NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.?Preliminary in vivo studies confirmed its promising pharmacokinetic profile.?NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test. |
Molecular Weight | 409.13 |
Formula | C20H23Cl2F2N3O2 |
CAS No. | T22379L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (26.89 mM)
You can also refer to dose conversion for different animals. More
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NLX-204 hydrochloride(2170405-10-2 free base) T22379L GPCR/G Protein Neuroscience 5-HT Receptor 2170405-10-2 free base NLX-204 Hydrochloride NLX204 Hydrochloride NLX 204 hydrochloride(2170405 10 2 free base) NLX 204 Hydrochloride 2170405-10-2 NLX204 hydrochloride(2170405102 free base) inhibitor inhibit