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Opiranserin hydrochloride

Catalog No. T9833 CAS 1440796-75-7

Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.

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Opiranserin hydrochloride Chemical Structure

Opiranserin hydrochloride, CAS 1440796-75-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 463.00
25 mg	In stock	$ 766.00
50 mg	In stock	$ 1,070.00
100 mg	In stock	$ 1,450.00
500 mg	In stock	$ 2,880.00
1 mL * 10 mM (in DMSO)	In stock	$ 318.00

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Biological Description

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Description	Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
Targets&IC50	5-HT2A receptor:1.3 μM, GlyT2:0.86 μM, P2X3 (rat):0.87 μM

Molecular Weight	430.97
Formula	C21H35ClN2O5
CAS No.	1440796-75-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (116.02 mM)

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Inhibitor Library GPCR Compound Library Anti-Cancer Drug Library Clinical Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Anti-Cancer Compound Library

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P2X3 antagonist 38 BzATP triethylammonium salt A-804598 RO-3 5-BDBD Minodronic acid Oxatomide JNJ-55308942

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Keywords

Opiranserin hydrochloride 1440796-75-7 GPCR/G Protein Membrane transporter/Ion channel Neuroscience 5-HT Receptor P2X Receptor GlyT VVZ 149 analgesic postoperative VVZ-149 5-hydroxytryptamine Receptor anti-inflammatory Serotonin Receptor Inhibitor pain Opiranserin non-opioid inhibit P2XRs Opiranserin Hydrochloride VVZ149 Glycine transporters inhibitor

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