non-opioid — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9833	Opiranserin hydrochloride		P2X Receptor , GlyT , 5-HT Receptor
	Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50...		P2X Receptor , GlyT , 5-HT Receptor
T6504	Flupirtine maleate	Katadolon maleate	Potassium Channel , NMDAR , iGluR
	Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener.		Potassium Channel , NMDAR , iGluR
TP1559L	Ziconotide Acetate (107452-89-1 free base)	Prialt,Ziconotide Acetate	Calcium Channel
	Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan...		Calcium Channel
T16399	Opiranserin		P2X Receptor , GlyT , 5-HT Receptor
	Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) an...		P2X Receptor , GlyT , 5-HT Receptor
T3720	Tebanicline hydrochloride	ABT-594 hydrochloride,Ebanicline hydrochloride	AChR
	Tebanicline hydrochloride (Ebanicline hydrochloride) , is an effective synthetic nicotinic (non-opioid) analgesic drug.		AChR
T39349	Vocacapsaicin hydrochloride	CA-008 hydrochloride	TRP/TRPV Channel
	Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.		TRP/TRPV Channel
T0470	Nefopam hydrochloride	Fenazoxine hydrochloride,Nefopam HCl	Wnt/beta-catenin , Sodium Channel
	Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.		Wnt/beta-catenin , Sodium Channel
T39529	AT-121 hydrochloride		Opioid Receptor
	AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and a...		Opioid Receptor
T8414	SNC 80	Snc-80,SNC80,NIH 10815	Opioid Receptor
	SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 show...		Opioid Receptor
T37610	AT-121		Opioid Receptor
	AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing either μ-opioid receptors or neuropeptide receptors...		Opioid Receptor
T27253	Elismetrep
	Elismetrep is a non-opioid analgesic.
T23972	DDD028	DDD 028,DDD-028
	DDD-028 is a potential non-opioid and non-cannabinoid analgesic. It was used for treating neuropathic and inflammatory pain.
T31631	Enkephalin-leu, ala(2)-ser(6)-	DALES,2-Ala-6-ser-leu-enkephalin
	Enkephalin-leu, ala(2)-ser(6)- is an active compound at the delta (non-complexed) opioid receptor.
T34784	TAN67	SB-205607 dihydrobromide,SB 205607 dihydrobromide,SB205607 dihydrobromide,TAN-67,TAN 67
	TAN67 is the first effective selective non-peptide delta1 opioid receptor.
T25690	Levallorphan tartrate	Lorfan
	Levallorphan tartrate is an opioid antagonist with properties similar to those of NALOXONE. Levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induce...
T26475	A-286501
	A-286501 is an orally active adenosine kinase inhibitor (IC50=0.47 nM). A-286501 effectively attenuates nociception by a non-opioid, non-non-steroidal anti-inflammatory drug ADO, receptor mediated mechanism.
T23313	SB 205607 dihydrobromide		Others
	non-peptide δ1 opioid receptor agonist		Others
T70503	Exp 631
	Exp 631 is a centrally-acting non-opioid analgesic; exhibits serotonin and norepinephrine reuptake inhibiting activities.
T39747	Nepinalone hydrochloride
	Nepinalone hydrochloride, a non-opioid antitussive, is an alchilaminate derivative of β-tetralone. This orally active compound effectively suppresses coughing.
T39348	Vocacapsaicin	CA-008,Vocacapsaicin
	Vocacapsaicin (CA-008), a prodrug of Capsaicin and a first-in-class non-opioid TRPV1 agonist, offers significant and enduring pain relief.
T69422	Flupirtine HCl
	Flupirtine HCl is the salt form of Flupirtine, also known as W-2964, an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the n...
T68933	Gaboxadol hydrobromide
	Gaboxadol hydrobromide is a GABA agonist. It is an inhibitor of GABA uptake systems. Gaboxadol can also be a non-opioid analgesic and a novel type of hypnotic.
T2806L	Lappaconitine HCl	Lappaconitine hydrochloride
	Lappaconitine HCl is a centrally acting non-opioid analgesic and class-I antiarrhythmic. It acts by binding to the site-2 receptor and irreversibly blocking hH1 sodium channels.
T12169	Naltrindole hydrochloride		Opioid Receptor
	Naltrindole hydrochloride is a selective and non-peptide δ opioid receptor antagonist(Ki = 0.02 nM).		Opioid Receptor
T71772	Bicifadine free base
	Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less ...
T27363	FR 64822	FR-64822,FR64822
	FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), a novel non-opioid antinociceptive compound, displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptiv...
T38192	Unifiram		Others
	Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra...		Others
T60473	Nepinalone
	Nepinalone is an alchilaminate derivative of β-tetralone. Nepinalone is an orally active cough suppressant that possesses a non-opioid antitussive activity [1].
T3694L	Tebanicline tosylate
	Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug. It was developed as a less toxic analogue of the potent poison dart frog-derived compound epibatidine. Like epibatidine, tebanicline showed potent ...
T73631	(Rac)-SNC80
	(Rac)-SNC80, a racemate of SNC80 (NIH 10815), is a potent, highly selective non-peptide δ-opioid receptor agonist, characterized by a K_i of 1.78 nM and an IC_50 of 2.73 nM. Demonstrating antinociceptive, antihyperalgesi...
T83709	LIH383 TFA	Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2
	LIH383 is a peptide agonist specifically designed to activate the chemokine (C-X-C motif) receptor 7 (CXCR7), which functions both as a chemokine and an opioid peptide scavenger receptor. Demonstrating a high selectivity...

Compounds

Opiranserin hydrochloride

T9833

Synonym:

Target: P2X Receptor, GlyT, 5-HT Receptor

Flupirtine maleate

T6504

Synonym: Katadolon maleate

Target: Potassium Channel, NMDAR, iGluR

Ziconotide Acetate (107452-89-1 free base)

TP1559L

Synonym: Prialt,Ziconotide Acetate

Target: Calcium Channel

Opiranserin

T16399

Synonym:

Target: P2X Receptor, GlyT, 5-HT Receptor

Tebanicline hydrochloride

T3720

Synonym: ABT-594 hydrochloride,Ebanicline hydrochloride

Target: AChR

Vocacapsaicin hydrochloride

T39349

Synonym: CA-008 hydrochloride

Target: TRP/TRPV Channel

Nefopam hydrochloride

T0470

Synonym: Fenazoxine hydrochloride,Nefopam HCl

Target: Wnt/beta-catenin, Sodium Channel

AT-121 hydrochloride

T39529

Synonym:

Target: Opioid Receptor

SNC 80

T8414

Synonym: Snc-80,SNC80,NIH 10815

Target: Opioid Receptor

AT-121

T37610

Synonym:

Target: Opioid Receptor

Synonym: DDD 028,DDD-028

Target:

Enkephalin-leu, ala(2)-ser(6)-

T31631

Synonym: DALES,2-Ala-6-ser-leu-enkephalin

Target:

TAN67

T34784

Synonym: SB-205607 dihydrobromide,SB 205607 dihydrobromide,SB205607 dihydrobromide,TAN-67,TAN 67

Target:

Levallorphan tartrate

SB 205607 dihydrobromide

Nepinalone hydrochloride

Synonym: CA-008,Vocacapsaicin

Gaboxadol hydrobromide

Synonym: Lappaconitine hydrochloride

Target:

Naltrindole hydrochloride

T12169

Synonym:

Target: Opioid Receptor

Synonym: FR-64822,FR64822

Synonym: Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2

Target:

Cat No.	Product Name	Synonyms	Targets
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
T23306	Salvinorin A		Opioid Receptor
	Salvinorin A is a non-nitrogenous κ-opioid selective agonist.		Opioid Receptor

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