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Piclidenoson

Catalog No. T7188 CAS 152918-18-8

Synonyms: CF-101, IB-MECA

Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.

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Piclidenoson, CAS 152918-18-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 59.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 328.00
50 mg	In stock	$ 528.00
100 mg	In stock	$ 822.00
200 mg	In stock	$ 1,090.00
500 mg	In stock	$ 1,650.00
1 mL * 10 mM (in DMSO)	In stock	$ 109.00

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Purity: 98%

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Description	Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
In vitro	Piclidenoson inhibited the proliferation of HaCat cells through deregulation of the NF-κB signaling pathway, leading to a decrease in interleukin-17 and interleukin-23 expression levels[1].
Cell Research	[3H]-Thymidine incorporation assay was used to evaluate cell growth.?HaCat cells (2500 cells/well) were incubated with piclidenoson 10?nM and MRS 1523 (50?nM) in 96-well plate for 48 hours.?For the last 24 hours of incubation, each well was pulsed with 1?mCi [3H]-thymidine.?Cells were harvested, and the [3H]-thymidine uptake was determined in an LKB liquid scintillation counter (LKB, Piscataway, NJ, USA).?These experiments were repeated at least 4 times[1].

Synonyms	CF-101, IB-MECA
Molecular Weight	510.29
Formula	C18H19IN6O4
CAS No.	152918-18-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (88.19 mM)

References and Literature

1. Cohen S , Barer F , Itzhak I , et al. Inhibition of IL-17 and IL-23 in Human Keratinocytes by the A 3 Adenosine Receptor Agonist Piclidenoson[J]. Journal of Immunology Research, 2018, 2018(1):1-8. 2. Abedi H , Aghaei M , Panjehpour M , et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines[J]. Tumor Biology, 2014, 35(11):11027-11039.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Fibrosis Compound Library Bioactive Compound Library Clinical Compound Library Anti-Infection Compound Library Neuronal Signaling Compound Library

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Keywords

Piclidenoson 152918-18-8 Apoptosis GPCR/G Protein Neuroscience Adenosine Receptor diseases P1 receptor CF-101 inhibit Inhibitor leukemia CF 101 CF101 prostate melanoma antiproliferative colon inflammatory breast autoimmune IB-MECA COVID-19 inhibitor

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