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Pimavanserin tartrate

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Purity:100%

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COA HNMR HPLC

Pimavanserin tartrate

Catalog No. T6946Cas No. 706782-28-7

Pimavanserin tartrate (Nuplazid) is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson's disease.

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Pack Size	Price	Availability
25 mg	$43	In Stock
50 mg	$68	In Stock
100 mg	$113	In Stock
200 mg	$146	In Stock
500 mg	$242	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description	Pimavanserin tartrate (Nuplazid) is an effective and specific serotonin 5-HT2A inverse agonist (pIC50: 8.73), used in the therapy of psychosis associated with Parkinson's disease.
In vivo	In rats, Pimavanserin (3 mg/kg, p.o.) attenuates DOI-induced head twitches. In mice, Pimavanserin (3 mg/kg, p.o.) significantly attenuates MK-801-induced hyperactivity. [1] In a rat model of parkinsonian tremor, Pimavanserin (40 mg/kg, i.p.) produces a significant overall reduction of tacrine-induced tremulous jaw movements. [2]
Alias	ACP-103, ACP-103 tartrate, Nuplazid, Pimavanserin

Chemical Properties

Molecular Weight	1005.2
Formula	C50H68F2N6O4·C4H6O6
Cas No.	706782-28-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 93 mg/mL (92.5 mM)

DMSO: 60 mg/mL (59.69 mM)

H2O: 92 mg/mL (91.5 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9948 mL	4.9741 mL	9.9483 mL	49.7413 mL
5 mM	0.1990 mL	0.9948 mL	1.9897 mL	9.9483 mL
10 mM	0.0995 mL	0.4974 mL	0.9948 mL	4.9741 mL
20 mM	0.0497 mL	0.2487 mL	0.4974 mL	2.4871 mL
50 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9948 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0099 mL	0.0497 mL	0.0995 mL	0.4974 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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