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Proguanil hydrochloride

Catalog No. T4382 CAS 637-32-1

Synonyms: Paludrine hydrochloride, Chlorguanide hydrochloride, Chloroquanil

Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.

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Proguanil hydrochloride Chemical Structure

Proguanil hydrochloride, CAS 637-32-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 60.00
25 mg	In stock	$ 102.00
50 mg	In stock	$ 190.00
100 mg	In stock	$ 340.00
200 mg	In stock	$ 545.00
500 mg	In stock	$ 878.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 98.34%

Purity: 98.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
In vitro	proguanil appeared to be a substrate of OCT1 and OCT2 with affinities of 8.1 and 9.0 μM, respectively
Cell Research	Sertoli cells obtained from sixteen to eighteen day-old-rats are cultured and treated with 0.3 μM to 10 μM of proguanil for 5 days after which Sertoli cell viability and nuclei integrity are determined. Also, the genetic expressions of transferrin and Glial cell line-derived neurotrophic factor are assessed. They are for reference only.
Animal Research	Proguanil is prepared in distilled water.Rats: Groups of ten to twelve-week-old rats are administered proguanil (2.9 mg/kg body weight) daily for 5 days and 6 weeks respectively. Thereafter, body and reproductive organ weights are taken, sperm parameters are analyzed, while the histology of the testis and epididymis are carried out. Also, serum levels of testosterone, luteinizing hormone and follicle stimulating hormone are determined. They are for reference only.

Synonyms	Paludrine hydrochloride, Chlorguanide hydrochloride, Chloroquanil
Molecular Weight	290.19
Formula	C11H17Cl2N5
CAS No.	637-32-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (189.53 mM)

References and Literature

1. Gerlinde F. Plöger, etal. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride[J]. Journal of Pharmaceutical Sciences, 2018, 163(4):1-21.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library FDA-Approved Drug Library Anti-Cancer Metabolism Compound Library Anti-Metabolism Disease Compound Library Metabolism Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Proguanil hydrochloride 637-32-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology Others Dehydrogenase DNA/RNA Synthesis Antifolate Parasite Proguanil infection Proguanil Hydrochloride biguanide Inhibitor Paludrine hydrochloride embryotoxicity toxicity inhibit reproductive Chlorguanide Hydrochloride Chlorguanide hydrochloride Chloroquanil Paludrine Hydrochloride antimalarial inhibitor

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