Home Tools
Log in
Cart

Rizatriptan benzoate

Catalog No. T1512   CAS 145202-66-0
Synonyms: MK-462 Benzoate

Rizatriptan benzoate (MK-462 Benzoate) selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Rizatriptan benzoate Chemical Structure
Rizatriptan benzoate, CAS 145202-66-0
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
25 mg In stock $ 72.00
50 mg In stock $ 128.00
100 mg In stock $ 193.00
200 mg In stock $ 287.00
500 mg In stock $ 486.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.72%
Purity: 99.422%
Purity: 99%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Rizatriptan benzoate (MK-462 Benzoate) selectively binds to and activates serotonin (5-HT) 1B receptors and 5-HT 1D receptors providing relief of migraine headaches.
In vivo Rizatriptan blocks neurogenic vasodilation via an action on 5-HT(1D) receptors located on perivascular trigeminal nerves to inhibit CGRP release in anaesthetized guinea-pigs. Rizatriptan evokes a transient reduction in dural blood vessel diameter which recovered to baseline values within 10?min in anaesthetized guinea-pigs. [1] Rizatriptan significantly inhibits dural plasma protein extravasation produced by high intensity electrical stimulation of the trigeminal ganglion. Rizatriptan significantly reduces electrically stimulated dural vasodilation in anaesthetised rats. [2] Rizatriptan Benzoate significantly reduced SP mRNA levels in the midbrains of normal and model group rats, indicating that Rizatriptan Benzoate can downregulate SP gene expression in the rat midbrain. Rizatriptan Benzoate significantly reduces midbrain PENK mRNA expression, decreasing the levels of midbrain met-enkephalin and leu-enkephalin, and thereby weakening the analgesic effects of the endogenous pain modulatory system in rat model of migraine. [3] Rizatriptan Benzoate leads to the number of Fos-like immunoreactive neurons decreased in the spinal trigeminal nucleus caudal partand raphe magnus nucleus, increased the number of Fos-like immunoreactive neurons in the periaqueductal gray and remained unchanged in the ventromedial hypothalamic nucleus and mediodorsal thalamus nucleus in conscious rats. [4] Rizatriptan Benzoate markedly reduces the number of head-flicks in the rats. Rizatriptan Benzoate also significantly reduces the duration of grooming behavior by nearly 2-fold when compared with that without treatment. [5]
Synonyms MK-462 Benzoate
Molecular Weight 391.47
Formula C22H25N5O2
CAS No. 145202-66-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 19.6 mg/mL (50 mM)

H2O: 39.2 mg/mL (100 mM)

TargetMolReferences and Literature

1. Williamson DJ, et al. Br J Pharmacol,2001, 133(7), 1029-1034. 2. Williamson DJ, et al. Eur J Pharmacol,1997, 328(1), 61-64. 3. Yao G, et al. Neural Regen Res,2012, 7(2), 131-135. 4. Wang X, et al. Brain Res, 2011, 1367, 340-346. 5. Dong Z, et al. Brain Res,2011, 1368, 151-158.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library FDA-Approved Drug Library Bioactive Compound Library Cardiotoxicity Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
Pergolide mesylate Sumatriptan succinate Lecozotan HCl Fluoxetine Dolasetron Mesylate hydrate Hypidone hydrochloride Niaprazine Cerlapirdine

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rizatriptan benzoate 145202-66-0 GPCR/G Protein Neuroscience 5-HT Receptor MK 462 Rizatriptan Rizatriptan Benzoate MK 462 Benzoate inhibit MK-462 Benzoate Inhibitor MK462 5-hydroxytryptamine Receptor MK-462 Serotonin Receptor MK462 Benzoate inhibitor

 

TargetMol