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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $84 | In Stock | |
10 mg | $137 | In Stock | |
25 mg | $277 | In Stock | |
50 mg | $445 | In Stock | |
100 mg | $659 | In Stock | |
500 mg | $1,380 | In Stock | |
1 mL x 10 mM (in DMSO) | $94 | In Stock |
Description | SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5). |
In vitro | SB 258719 antagonised surmountably 5-CT-stimulated adenylyl cyclase activity. Schild analysis of the antagonism by SB 258719 gave a pA2 of 7.2±0.2 and slope not significantly different from 1, consistent with competitive antagonism[3]. |
In vivo | SB 258719 (5-20 mg/kg, i.p.) reversed the hypothermic effect of 5-CT in mice[1]. Increased Wnt/β-catenin activity was attenuated by SB 258719 in HCC cell lines and patient-derived primary tumour tissues in the presence of 5-HT. SB 258719 also reduced tumour growth in vivo[2]. |
Molecular Weight | 338.51 |
Formula | C18H30N2O2S |
Cas No. | 195199-95-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 250 mg/mL (738.53 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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