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SHR0302

Catalog No. T9195 CAS 1445987-21-2

Synonyms: ARQ252

SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).

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SHR0302, CAS 1445987-21-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 187.00
2 mg	In stock	$ 279.00
5 mg	In stock	$ 472.00
10 mg	In stock	$ 747.00
25 mg	In stock	$ 1,270.00
50 mg	In stock	$ 1,690.00
100 mg	In stock	$ 2,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 543.00

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Purity: 99.11%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).
In vitro	SHR0302 (1nM-10μM) exerted an inhibitory effect on the activation, proliferation and migration of hepatic stellate cells (HSCs). SHR0302 induced the apoptosis of HSCs. The pharmacological inhibition of the JAK1/signal transducer and activator of transcription (STAT)3 pathway led to the disruption of functions essential for HSC[1].
In vivo	SHR0302 may attenuate the severity of AA rats, partially through reducing Th17 function and total B cell proportion by inhibiting JAK1-STAT3 phosphorylation[2].

Synonyms	ARQ252
Molecular Weight	414.48
Formula	C18H22N8O2S
CAS No.	1445987-21-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL(72.38 mM), Sonification is recommended.

References and Literature

1. Gu Y J , Sun W Y , Zhang S , et al. Targeted blockade of JAK/STAT3 signaling inhibits proliferation, migration and collagen production as well as inducing the apoptosis of hepatic stellate cells[J]. International Journal of Molecular Medicine, 2016. 2. JAK1-STAT3 blockade by JAK inhibitor SHR0302 attenuates inflammatory responses of adjuvant-induced arthritis rats and decreases Th17 and total Bcells[J]. Joint Bone Spine Revue Du Rhumatisme, 2016:525-532.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Orally Active Compound Library Anti-Pancreatic Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Epigenetics Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SHR0302 1445987-21-2 Angiogenesis Apoptosis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK Th17 B-cell Inhibitor inhibit arthritis collagen migration hepatic ARQ 252 JAK1 phosphorylation anti-proliferation ARQ252 ARQ-252 JAK1-STAT3 SHR 0302 fibrosis SHR-0302 anti-inflammatory Janus kinase inhibitor

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