keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
2 mg | In stock | $ 126.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 328.00 | |
25 mg | In stock | $ 663.00 | |
50 mg | In stock | $ 1,060.00 | |
100 mg | In stock | $ 1,630.00 | |
500 mg | In stock | $ 3,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 226.00 |
Description | TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM). |
Targets&IC50 | EGFR:1.1-8.0 nM |
In vitro | TAS6417 inhibits the growth of cells expressing exon 20 insertion mutations of the EGFR gene (GI50 value of 86.5±28.5 nM for LXF 2478L cells and 45.4±2.6 nM for NCI-H1975 EGFR D770_N771insSVD cells). TAS6417 also potently inhibits proliferation in other cell lines harboring activating mutations or acquired resistance mutations (mean GI50: 1.92±0.21 nM to 7.12±0.60 nM) [1]. |
In vivo | TAS6417 inhibits mutant EGFR in tumors but not WT EGFR in skin tissues. TAS6417 induces persistent tumor regression in vivo in EGFR exon 20 insertion-driven tumor models [1]. |
Molecular Weight | 396.44 |
Formula | C23H20N6O |
CAS No. | 1661854-97-2 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (315.31 mM)
You can also refer to dose conversion for different animals. More
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TAS6417 1661854-97-2 Angiogenesis Apoptosis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR ErbB-1 TAS-6417 PC-9 lung Inhibitor CLN081 BEAS-2B CLN 081 cancer BID007 CLN-081 inhibit NSCLC H1975 Epidermal growth factor receptor BID019 HER1 Akt TAS 6417 inhibitor