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TAS6417

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Purity:99.19%

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COA HNMR HPLC

TAS6417

Catalog No. T16996Cas No. 1661854-97-2

TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).

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Pack Size	Price	Availability
1 mg	$89	In Stock
2 mg	$126	In Stock
5 mg	$198	In Stock
10 mg	$328	In Stock
25 mg	$663	In Stock
50 mg	$1,060	In Stock
100 mg	$1,630	In Stock
500 mg	$3,280	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock

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Product Introduction

Bioactivity

Description	TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
In vitro	TAS6417 inhibits the growth of cells expressing exon 20 insertion mutations of the EGFR gene (GI50 value of 86.5±28.5 nM for LXF 2478L cells and 45.4±2.6 nM for NCI-H1975 EGFR D770_N771insSVD cells). TAS6417 also potently inhibits proliferation in other cell lines harboring activating mutations or acquired resistance mutations (mean GI50: 1.92±0.21 nM to 7.12±0.60 nM) [1].
In vivo	TAS6417 inhibits mutant EGFR in tumors but not WT EGFR in skin tissues. TAS6417 induces persistent tumor regression in vivo in EGFR exon 20 insertion-driven tumor models [1].

Chemical Properties

Molecular Weight	396.44
Formula	C23H20N6O
Cas No.	1661854-97-2

Storage & Solubility Information

Storage

keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (138.73 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5224 mL	12.6122 mL	25.2245 mL	126.1225 mL
5 mM	0.5045 mL	2.5224 mL	5.0449 mL	25.2245 mL
10 mM	0.2522 mL	1.2612 mL	2.5224 mL	12.6122 mL
20 mM	0.1261 mL	0.6306 mL	1.2612 mL	6.3061 mL
50 mM	0.0504 mL	0.2522 mL	0.5045 mL	2.5224 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2612 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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