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TL02-59

Catalog No. T13186Cas No. 1315330-17-6

TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia cell growth.

TL02-59

TL02-59

Purity: 95.63%
Catalog No. T13186Cas No. 1315330-17-6
TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia cell growth.
Pack SizePriceAvailabilityQuantity
1 mg$65In Stock
5 mg$137In Stock
10 mg$223In Stock
25 mg$377In Stock
50 mg$538In Stock
100 mg$732In Stock
200 mg$986In Stock
1 mL x 10 mM (in DMSO)$178In Stock
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Purity:95.63%
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Product Introduction

Bioactivity
Description
TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia cell growth.
Targets&IC50
Lyn:0.1 nM , FGR:0.03 nM , Hck:160 nM
In vitro
TL02-59 inhibits the growth and induced apoptosis of AML cell lines expressing this kinase with single-digit nM potency. TL02-59 induces growth arrest in primary AML bone marrow samples. In TF-1 myeloid cells, TL02-59 (0.1, 1, 10, 100, 1000 nM; 6 h) potently inhibits Fgr autophosphorylation in TF-1 cells, with paritial inhibition at 0.1-1 nM and complete inhibition above 10 nM. Hck, Lyn and Flt3 are inhibited in the 100 to 1000 nM range[1].
In vivo
In mice, TL02-59 (1, 10 mg/kg; oral) completely eliminates AML cells from the spleen and peripheral blood while dramatically suppressing bone marrow involvement. TL02-59 has a t1/2 of 5.7 h by i.v and 6.5 h by p.o., respectively[1].
Chemical Properties
Molecular Weight609.64
FormulaC32H34F3N5O4
Cas No.1315330-17-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 120 mg/mL (196.84 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6403 mL8.2016 mL16.4031 mL82.0156 mL
5 mM0.3281 mL1.6403 mL3.2806 mL16.4031 mL
10 mM0.1640 mL0.8202 mL1.6403 mL8.2016 mL
20 mM0.0820 mL0.4101 mL0.8202 mL4.1008 mL
50 mM0.0328 mL0.1640 mL0.3281 mL1.6403 mL
100 mM0.0164 mL0.0820 mL0.1640 mL0.8202 mL

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