Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 178.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 528.00 | |
50 mg | In stock | $ 743.00 | |
100 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. |
In vivo | Tavapadon (0.1 mg/kg; s.c.) has the mean maximal unbound plasma concentration of 8 nM and achieves 3 hours after compound administration in captive-bred macaques. Tavapadon (0.02 and 0.04 mg/kg; s.c.) at the 0.04 mg/kg test dose increases locomotor activity, whereas the 0.02 mg/kg dose has little or no effect. Tavapadon (0.04 mg/kg, s.c.) also improves parkinsonian disability scores with the maximal improvement observed at 110 min after drug administration. Higher doses of Tavapadon (0.1 and 0.15 mg/kg; s.c.) cause statistically significant improvement relative to vehicle in locomotor activity [1]. |
Synonyms | PF-6649751, CVL-751 |
Molecular Weight | 391.34 |
Formula | C19H16F3N3O3 |
CAS No. | 1643489-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (153.32 mM)
You can also refer to dose conversion for different animals. More
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Tavapadon 1643489-24-0 GPCR/G Protein Neuroscience Dopamine Receptor PF 6649751 CVL 751 inhibit PF 06649751 Inhibitor PF-06649751 PF06649751 PF6649751 CVL751 PF-6649751 CVL-751 inhibitor