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Tirbanibulin Mesylate

Catalog No. T15675   CAS 1080645-95-9
Synonyms: KX2-391 Mesylate, KX01 Mesylate

Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).

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Tirbanibulin Mesylate Chemical Structure
Tirbanibulin Mesylate, CAS 1080645-95-9
Pack Size Availability Price/USD Quantity
2 mg In stock $ 32.00
5 mg In stock $ 51.00
10 mg In stock $ 64.00
25 mg In stock $ 128.00
50 mg In stock $ 255.00
100 mg In stock $ 438.00
200 mg In stock $ 591.00
1 mL * 10 mM (in DMSO) In stock $ 59.00
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Purity: 99.42%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
Targets&IC50 Src:13 nM(in PLC/PRF/5 cells), Src:26 nM(in Hep3B cells), Src:60 nM(in HepG2 cells), Src:9 nM (GI50, in HuH7 cells)
In vitro Tirbanibulin Mesylate is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. Tirbanibulin Mesylate displays steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines [1]. Tirbanibulin Mesylate is evaluated in engineered Src drove cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively [2].
In vivo In pre-clinical animal models of cancer, Tirbanibulin Mesylate (p.o.) is shown to inhibit primary tumor growth and to suppress metastasis [2].
Synonyms KX2-391 Mesylate, KX01 Mesylate
Molecular Weight 527.63
Formula C27H33N3O6S
CAS No. 1080645-95-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 99 mg/mL (187.63 mM), sonification is recommended.

TargetMolReferences and Literature

1. Lau GM, et al. Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Dig Dis Sci, 2009, 54(7), 1465-1474. 2. Fallah-Tafti A, et al. Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities. Eur J Med Chem, 2011, 46(10), 4853-4858.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Microtubule-Targeted Compound Library FDA-Approved Drug Library Approved Drug Library Bioactive Compound Library Cytoskeletal Signaling Pathway Compound Library

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Keywords

Tirbanibulin Mesylate 1080645-95-9 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Src Microtubule Associated KX01 KX-01 Mesylate KX2-391 KX 01 Mesylate Inhibitor KX2-391 Mesylate inhibit KX-01 Tirbanibulin KX 01 Microtubule/Tubulin KX01 Mesylate inhibitor

 

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