Shopping Cart

Remove All

Your shopping cart is currently empty

Tirbanibulin Mesylate

Select Batch

Purity:99.42%

Resource Download

COA HNMR HPLC

Tirbanibulin Mesylate

Catalog No. T15675Cas No. 1080645-95-9

Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$32	In Stock
5 mg	$51	In Stock
10 mg	$64	In Stock
25 mg	$128	In Stock
50 mg	$255	In Stock
100 mg	$438	In Stock
200 mg	$591	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Tirbanibulin Mesylate"

Product Introduction

Bioactivity

Description	Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
In vitro	Tirbanibulin Mesylate is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. Tirbanibulin Mesylate displays steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines [1]. Tirbanibulin Mesylate is evaluated in engineered Src drove cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively [2].
In vivo	In pre-clinical animal models of cancer, Tirbanibulin Mesylate (p.o.) is shown to inhibit primary tumor growth and to suppress metastasis [2].
Alias	KX2-391 Mesylate, KX01 Mesylate

Chemical Properties

Molecular Weight	527.63
Formula	C27H33N3O6S
Cas No.	1080645-95-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 99 mg/mL (187.63 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8953 mL	9.4763 mL	18.9527 mL	94.7634 mL
5 mM	0.3791 mL	1.8953 mL	3.7905 mL	18.9527 mL
10 mM	0.1895 mL	0.9476 mL	1.8953 mL	9.4763 mL
20 mM	0.0948 mL	0.4738 mL	0.9476 mL	4.7382 mL
50 mM	0.0379 mL	0.1895 mL	0.3791 mL	1.8953 mL
100 mM	0.0190 mL	0.0948 mL	0.1895 mL	0.9476 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc