Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 51.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 255.00 | |
100 mg | In stock | $ 438.00 | |
200 mg | In stock | $ 591.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 59.00 |
Description | Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines). |
Targets&IC50 | Src:13 nM(in PLC/PRF/5 cells), Src:26 nM(in Hep3B cells), Src:60 nM(in HepG2 cells), Src:9 nM (GI50, in HuH7 cells) |
In vitro | Tirbanibulin Mesylate is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. Tirbanibulin Mesylate displays steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines [1]. Tirbanibulin Mesylate is evaluated in engineered Src drove cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively [2]. |
In vivo | In pre-clinical animal models of cancer, Tirbanibulin Mesylate (p.o.) is shown to inhibit primary tumor growth and to suppress metastasis [2]. |
Synonyms | KX2-391 Mesylate, KX01 Mesylate |
Molecular Weight | 527.63 |
Formula | C27H33N3O6S |
CAS No. | 1080645-95-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 99 mg/mL (187.63 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Tirbanibulin Mesylate 1080645-95-9 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Src Microtubule Associated KX01 KX-01 Mesylate KX2-391 KX 01 Mesylate Inhibitor KX2-391 Mesylate inhibit KX-01 Tirbanibulin KX 01 Microtubule/Tubulin KX01 Mesylate inhibitor