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Vanoxerine dihydrochloride

Catalog No. T7153 CAS 67469-78-7

Synonyms: GBR-12909 dihydrochloride, I893 dihydrochloride

Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor that blocks dopamine uptake (IC50 : 1-51 nM)

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Vanoxerine dihydrochloride Chemical Structure

Vanoxerine dihydrochloride, CAS 67469-78-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 94.00
50 mg	In stock	$ 138.00
100 mg	In stock	$ 198.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 97.10%

Biological Description

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Description	Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor that blocks dopamine uptake (IC50 : 1-51 nM)
Targets&IC50	Dopamine uptake:1-51 nM
In vivo	In 9 SP dogs, 11 episodes each of sustained (>10 minutes) AF and AFL were induced. Electrophysiological studies were performed before and after infusion of vanoxerine, which effectively terminated AF and AFL in 19 of 22 episodes. Simultaneous multisite mapping during 3 AF and 3 AFL episodes demonstrated that termination of each arrhythmia occurred with termination of the driver (a reentrant circuit) following an increase in tachycardia CL. Except for conduction in an area of slow conduction in the driver's reentrant circuit, vanoxerine did not significantly affect intraatrial or atrioventricular conduction time, QRS duration, or QT/QTc intervals. Ventricular refractoriness prolonged minimally during ventricular pacing at 400 and 333 ms (176 +/- 16 ms to 182 +/- 16 ms; 173 +/- 11 ms to 178 +/- 18 ms, respectively). Vanoxerine minimally increased (mean 0.7 mA) atrial stimulus threshold for capture[1].Vanoxerine dihydrochloridealso blocks ligand binding to sigma receptors in rat brain (IC50 = 48 nM)[2].

Synonyms	GBR-12909 dihydrochloride, I893 dihydrochloride
Molecular Weight	523.49
Formula	C28H34Cl2F2N2O
CAS No.	67469-78-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9.4 mg/mL (17.96 mM)

References and Literature

1. Vanoxerine, a New Drug for Terminating Atrial Fibrillation and Flutter[J]. J Cardiovasc Electrophysiol, 2010, 21(3):311-319. 2. Contreras P C , Bremer M E , Rao T S . GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain[J]. Life Sciences, 1990, 47(22):PL133-7. 3. Rothman R B , Baumann M H , Prisinzano T E , et al. Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction[J]. Biochemical Pharmacology, 2008, 75(1):2-16.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Inhibitor Library GPCR Compound Library Anti-Cancer Drug Library Anti-Parkinson's Disease Compound Library Immunology/Inflammation Compound Library Clinical Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

A 77636 hydrochloride PF-00217830 Talipexole dihydrochloride Benztropine mesylate Escitalopram Pridopidine Blonanserin Metoclopramide hydrochloride

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Keywords

Vanoxerine dihydrochloride 67469-78-7 GPCR/G Protein Neuroscience Dopamine Receptor GBR-12909 GBR-12909 dihydrochloride I 893 Inhibitor SLC6A3 Vanoxerine GBR12909 inhibit I-893 DAT I893 Dihydrochloride GBR 12909 Dihydrochloride I 893 Dihydrochloride I-893 Dihydrochloride GBR12909 Dihydrochloride Dopamine Transporter I893 dihydrochloride GBR 12909 I893 GBR-12909 Dihydrochloride Vanoxerine Dihydrochloride inhibitor

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