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Vanoxerine dihydrochloride
🥰Excellent
Catalog No. T7153Cas No. 67469-78-7
Alias I893 dihydrochloride, GBR-12909 dihydrochloride
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor of dopamine uptake (IC50: 1-51 nM).
Vanoxerine dihydrochloride
🥰Excellent
Purity: 98.35%
Catalog No. T7153Alias I893 dihydrochloride, GBR-12909 dihydrochlorideCas No. 67469-78-7
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor of dopamine uptake (IC50: 1-51 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $44 | In Stock | |
| 25 mg | $78 | In Stock | |
| 50 mg | $123 | In Stock | |
| 100 mg | $179 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $31 | In Stock |
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Purity:98.35%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor of dopamine uptake (IC50: 1-51 nM). |
| Targets&IC50 | Dopamine uptake:1-51 nM |
| In vivo | In 9 SP dogs, 11 episodes each of sustained (>10 minutes) AF and AFL were induced. Electrophysiological studies were performed before and after infusion of vanoxerine, which effectively terminated AF and AFL in 19 of 22 episodes. Simultaneous multisite mapping during 3 AF and 3 AFL episodes demonstrated that termination of each arrhythmia occurred with termination of the driver (a reentrant circuit) following an increase in tachycardia CL. Except for conduction in an area of slow conduction in the driver's reentrant circuit, vanoxerine did not significantly affect intraatrial or atrioventricular conduction time, QRS duration, or QT/QTc intervals. Ventricular refractoriness prolonged minimally during ventricular pacing at 400 and 333 ms (176 +/- 16 ms to 182 +/- 16 ms; 173 +/- 11 ms to 178 +/- 18 ms, respectively). Vanoxerine minimally increased (mean 0.7 mA) atrial stimulus threshold for capture[1].Vanoxerine dihydrochloridealso blocks ligand binding to sigma receptors in rat brain (IC50 = 48 nM)[2]. |
| Alias | I893 dihydrochloride, GBR-12909 dihydrochloride |
| Molecular Weight | 523.49 |
| Formula | C28H34Cl2F2N2O |
| Cas No. | 67469-78-7 |
| Smiles | Cl.Cl.Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 9.4 mg/mL (17.96 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Vanoxerine dihydrochlorideVanoxerine DihydrochlorideVanoxerineSLC6A3InhibitorinhibitI-893 DihydrochlorideI893 DihydrochlorideI-893I893I 893 DihydrochlorideI 893GBR-12909 DihydrochlorideGBR12909 DihydrochlorideGBR-12909GBR12909GBR 12909 DihydrochlorideGBR 12909DopamineReceptordopamine uptakeDopamine TransporterDopamine ReceptorDAT
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