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AMD 3465 hexahydrobromide

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Purity:99.03%

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COA HNMR HPLC MS

AMD 3465 hexahydrobromide

Catalog No. T7208Cas No. 185991-07-5

AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.

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Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$51	In Stock
10 mg	$72	In Stock
25 mg	$141	In Stock
50 mg	$243	In Stock
100 mg	$383	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Product Introduction

Bioactivity

Description	AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
In vitro	AMD 3465 hexahydrobromide inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.?AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells.?AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.?AMD3465 is cytotoxic to the X4 HIV-1 strains IIIB, NL4.3, RF and HE with an IC50 ranging from 6 to 12 nM.?The IC50 for suppression of the HIV-2 strains ROD and EHO is 12.3 nM[1].?AMD 3465 inhibits CXCL-12-induced growth in U87 and Daoy cells.?AMD 3465 treatment stimulates the phosphorylation of Erk1/2 in U87 and Daoy cells[2].
In vivo	Administering 2.5 mg/kg/d of AMD 3465 subcutaneously for five weeks significantly inhibits the growth of U87 glioblastoma multiforme (GBM) and Daoy medulloblastoma xenografts.
Alias	GENZ-644494 (hexahydrobromide)

Chemical Properties

Molecular Weight	896.07
Formula	C24H44Br6N6
Cas No.	185991-07-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 38 mg/mL (42.41 mM)

DMSO: 50 mg/mL (55.80 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.1160 mL	5.5799 mL	11.1598 mL	55.7992 mL
5 mM	0.2232 mL	1.1160 mL	2.2320 mL	11.1598 mL
10 mM	0.1116 mL	0.5580 mL	1.1160 mL	5.5799 mL
20 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7900 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0223 mL	0.1116 mL	0.2232 mL	1.1160 mL
100 mM	0.0112 mL	0.0558 mL	0.1116 mL	0.5580 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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