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CHM-1
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Catalog No. T22661Cas No. 154554-41-3
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
CHM-1
🥰Excellent
Purity: 100%
Catalog No. T22661Cas No. 154554-41-3
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $47 | In Stock | |
| 10 mg | $80 | In Stock | |
| 25 mg | $172 | In Stock | |
| 50 mg | $238 | In Stock | |
| 100 mg | $359 | In Stock | |
| 200 mg | $512 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. |
| Targets&IC50 | Apoptosis:0.75 μM (HA22T) |
| In vitro | CHM-1 (0-10 μM; 24 hours) significantly increased the binding of cyclin B1 to Cdc2 and induced change in expressed and phosphorylated status of G2-M regulators in HA22T cells. CHM-1 (0-100μM; 24 hours) induced significant concentration-dependent growth inhibition in HA22T, Hep3B, and HepG2 cells, with the most potent effects observed in HA22T cells with an IC50 of 0.75 μM)[3]. |
| In vivo | In male severe combined immunodeficient mice, CHM-1 (10 mg/kg; i.p.) induced inhibition of HA22T tumor growth in a dose-dependent manner[3]. |
| Molecular Weight | 283.25 |
| Formula | C16H10FNO3 |
| Cas No. | 154554-41-3 |
| Smiles | O=C1C2=C(NC(=C1)C3=C(F)C=CC=C3)C=C4C(=C2)OCO4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/mL  H2O: < 7.08 mg/mL |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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