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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
2 mg | $48 | In Stock | |
5 mg | $79 | In Stock | |
10 mg | $133 | In Stock | |
25 mg | $286 | In Stock | |
50 mg | $397 | In Stock | |
100 mg | $598 | In Stock | |
500 mg | Inquiry | In Stock |
Description | CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. |
In vitro | CHM-1 (0-10 μM; 24 hours) significantly increased the binding of cyclin B1 to Cdc2 and induced change in expressed and phosphorylated status of G2-M regulators in HA22T cells. CHM-1 (0-100μM; 24 hours) induced significant concentration-dependent growth inhibition in HA22T, Hep3B, and HepG2 cells, with the most potent effects observed in HA22T cells with an IC50 of 0.75 μM)[3]. |
In vivo | In male severe combined immunodeficient mice, CHM-1 (10 mg/kg; i.p.) induced inhibition of HA22T tumor growth in a dose-dependent manner[3]. |
Molecular Weight | 283.25 |
Formula | C16H10FNO3 |
Cas No. | 154554-41-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: 1mg/ml ![]() H2O: < 7.08 mg/mL |
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