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Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enantiomer.Citalopram exhibits antidepressant activity and enhances serotonergic neurotransmission. It can be used to study Alzheimer's disease.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $30 | In Stock | |
50 mg | $41 | In Stock | |
100 mg | $64 | In Stock | |
500 mg | $153 | In Stock | |
1 mL x 10 mM (in DMSO) | $46 | In Stock |
Description | Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enantiomer.Citalopram exhibits antidepressant activity and enhances serotonergic neurotransmission. It can be used to study Alzheimer's disease. |
In vitro | Citalopram exhibits concentration-dependent cytotoxicity when applied at concentrations ranging from 25 to 175 μM for 24 hours[4]. Specifically, at a concentration of 100 μM for 24 hours, Citalopram strongly downregulates the expression of MYBL2, BIRC5, BARD1, AURKA, CCNA2, and CCNE1 in B104 cells[4]. |
In vivo | Administered via intraperitoneal injection at doses ranging from 5 to 40 mg/kg, Citalopram reduces immobility time in DBA/2J mice but does not elicit a similar effect in C57BL/6J mice[3]. |
Alias | Lu-10-171 Lu10-171, Lu 10-171, Cipram |
Molecular Weight | 324.39 |
Formula | C20H21FN2O |
Cas No. | 59729-33-8 |
Smiles | CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1 |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (123.31 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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