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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $31 | In Stock | |
2 mg | $44 | In Stock | |
5 mg | $72 | In Stock | |
10 mg | $114 | In Stock | |
25 mg | $230 | In Stock | |
50 mg | $345 | In Stock | |
100 mg | $520 | In Stock | |
500 mg | $996 | In Stock | |
1 mL x 10 mM (in DMSO) | $81 | In Stock |
Description | Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases. |
Targets&IC50 | Prolyl-tRNA synthetase:18.3±0.5 nM(ki) |
Alias | Tempostatin, RU-19110 (hydrobromide), Stenorol |
Molecular Weight | 495.59 |
Formula | C16H17BrClN3O3.HBr |
Cas No. | 64924-67-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 12 mg/mL (24.21 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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