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Halofuginone hydrobromide

🥰Excellent
Catalog No. T3524Cas No. 64924-67-0
Alias Tempostatin, Stenorol, RU-19110 (hydrobromide)

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.

Halofuginone hydrobromide

Halofuginone hydrobromide

🥰Excellent
Purity: 98.5%
Catalog No. T3524Alias Tempostatin, Stenorol, RU-19110 (hydrobromide)Cas No. 64924-67-0
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
2 mg$44In Stock
5 mg$72In Stock
10 mg$114In Stock
25 mg$230In Stock
50 mg$345In Stock
100 mg$520In Stock
500 mg$996In Stock
1 mL x 10 mM (in DMSO)$81In Stock
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Purity:98.5%
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Product Introduction

Bioactivity
Description
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
Targets&IC50
Prolyl-tRNA synthetase:18.3±0.5 nM(ki)
AliasTempostatin, Stenorol, RU-19110 (hydrobromide)
Chemical Properties
Molecular Weight495.59
FormulaC16H17BrClN3O3.HBr
Cas No.64924-67-0
SmilesBr.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12 mg/mL (24.21 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0178 mL10.0890 mL20.1780 mL100.8898 mL
5 mM0.4036 mL2.0178 mL4.0356 mL20.1780 mL
10 mM0.2018 mL1.0089 mL2.0178 mL10.0890 mL
20 mM0.1009 mL0.5044 mL1.0089 mL5.0445 mL

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