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JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $42 | In Stock | |
25 mg | $78 | In Stock | |
50 mg | $125 | In Stock | |
100 mg | $197 | In Stock | |
1 mL x 10 mM (in DMSO) | $32 | In Stock |
Description | JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively. |
Targets&IC50 | M4Di DREADD (human):0.2 nM (EC50), M3Dq DREADD (human):18.5 nM (EC50) |
In vitro | JHU 37160 is a potent agonist of DREADD with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells |
In vivo | JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice |
Alias | JHU 37160 |
Molecular Weight | 358.84 |
Formula | C19H20ClFN4 |
Cas No. | 2369979-68-8 |
Smiles | CCN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c(F)cccc12 |
Relative Density. | 1.34 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 72 mg/mL (200.65 mM) DMSO: 72 mg/mL (200.65 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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