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JHU37160

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Purity:99.25%

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COA HPLC HNMR

JHU37160

Catalog No. T9018Cas No. 2369979-68-8

JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.

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Pack Size	Price	Availability
10 mg	$42	In Stock
25 mg	$78	In Stock
50 mg	$125	In Stock
100 mg	$197	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock

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Product Introduction

Bioactivity

Description	JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
Targets&IC50	M4Di DREADD (human):0.2 nM (EC50), M3Dq DREADD (human):18.5 nM (EC50)
In vitro	JHU 37160 is a potent agonist of DREADD with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells
In vivo	JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice
Alias	JHU 37160

Chemical Properties

Molecular Weight	358.84
Formula	C19H20ClFN4
Cas No.	2369979-68-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 72 mg/mL (200.65 mM)

DMSO: 72 mg/mL (200.65 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7868 mL	13.9338 mL	27.8676 mL	139.3379 mL
5 mM	0.5574 mL	2.7868 mL	5.5735 mL	27.8676 mL
10 mM	0.2787 mL	1.3934 mL	2.7868 mL	13.9338 mL
20 mM	0.1393 mL	0.6967 mL	1.3934 mL	6.9669 mL
50 mM	0.0557 mL	0.2787 mL	0.5574 mL	2.7868 mL
100 mM	0.0279 mL	0.1393 mL	0.2787 mL	1.3934 mL

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