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LE 300

🥰Excellent
Catalog No. T22921Cas No. 274694-98-3

LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.

LE 300

LE 300

🥰Excellent
Purity: 98.35%
Catalog No. T22921Cas No. 274694-98-3
LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.
Pack SizePriceAvailabilityQuantity
1 mg$89In Stock
5 mg$219In Stock
10 mg$326In Stock
25 mg$546In Stock
50 mg$778In Stock
100 mg$1,060In Stock
500 mg$2,120In Stock
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Purity:98.35%
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Product Introduction

Bioactivity
Description
dopamine D1 receptor antagonist
Targets&IC50
D5 receptor:7.5 nM (Ki,Human), 5-HT2A:8.32 (pA2,rat), D1 receptor:1.9 nM (Ki,Human)
In vitro
The Kis of LE 300 are 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. In a rat tail artery experiment, the pA2 value of LE 300 at the 5-HT2A receptor was 8.32[2].
Chemical Properties
Molecular Weight290.4
FormulaC20H22N2
Cas No.274694-98-3
SmilesCN(CCc1c(C2)[nH]c3c1cccc3)CCc1c2cccc1
Relative Density.1.114g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
1eq. HCl: <15 mg/mL (51.65 mM)
DMSO: <30 mg/mL (103.30 mM)
Solution Preparation Table
1eq. HCl/DMSO
1mg5mg10mg50mg
1 mM3.4435 mL17.2176 mL34.4353 mL172.1763 mL
5 mM0.6887 mL3.4435 mL6.8871 mL34.4353 mL
10 mM0.3444 mL1.7218 mL3.4435 mL17.2176 mL
20 mM0.1722 mL0.8609 mL1.7218 mL8.6088 mL
50 mM0.0689 mL0.3444 mL0.6887 mL3.4435 mL
DMSO
1mg5mg10mg50mg
100 mM0.0344 mL0.1722 mL0.3444 mL1.7218 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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Keywords

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