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Litoxetine
🥰Excellent
Catalog No. T67956Cas No. 86811-09-8
Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently reduced the number of regurgitations and vomiting and delayed the onset of vomiting. Litoxetine has an affinity for brain 5HT3 receptors (Ki = 85 nM).
Litoxetine
🥰Excellent
Purity: 99.12%
Catalog No. T67956Cas No. 86811-09-8
Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently reduced the number of regurgitations and vomiting and delayed the onset of vomiting. Litoxetine has an affinity for brain 5HT3 receptors (Ki = 85 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 93 € | In Stock | |
| 5 mg | 217 € | In Stock | |
| 10 mg | 325 € | In Stock | |
| 25 mg | 556 € | In Stock | |
| 50 mg | 796 € | In Stock | |
| 100 mg | 1.102 € | In Stock | |
| 500 mg | 2.204 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 188 € | In Stock |
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Purity:99.12%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently reduced the number of regurgitations and vomiting and delayed the onset of vomiting. Litoxetine has an affinity for brain 5HT3 receptors (Ki = 85 nM). |
| Targets&IC50 | [3H]-DAU 6215:0.3 microM |
| In vitro | Litoxetine (0.3-3 microM) antagonized the high- and low-potency phases of the 5-HT curve.[1] Litoxetine (1 and 3 microM) responses to 5-MeOT were shifted to the right in a concentration-dependent manner.[1] |
| In vivo | Litoxetine (twice daily for 4 days), a novel specific serotonin reuptake inhibitor.[2] |
| Molecular Weight | 241.33 |
| Formula | C16H19NO |
| Cas No. | 86811-09-8 |
| Smiles | C(OC1CCNCC1)C2=CC3=C(C=C2)C=CC=C3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (41.44 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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