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Lofepramine
🥰Excellent
Catalog No. T15773Cas No. 23047-25-8
Alias Lopramine, Leo 640, Gamanil, Amplit
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
Lofepramine
🥰Excellent
Purity: 98.38%
Catalog No. T15773Alias Lopramine, Leo 640, Gamanil, AmplitCas No. 23047-25-8
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $41 | In Stock | |
| 5 mg | $66 | In Stock | |
| 10 mg | $91 | In Stock | |
| 25 mg | $188 | In Stock | |
| 50 mg | $281 | In Stock | |
| 100 mg | $422 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $72 | In Stock |
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CitedSelect Batch
Purity:98.38%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors. |
| Targets&IC50 | 5-HT:70 nM(Kd), NET:5.4 nM(Kd) |
| Alias | Lopramine, Leo 640, Gamanil, Amplit |
| Molecular Weight | 418.96 |
| Formula | C26H27ClN2O |
| Cas No. | 23047-25-8 |
| Smiles | C(CCN(CC(=O)C1=CC=C(Cl)C=C1)C)N2C=3C(CCC=4C2=CC=CC4)=CC=CC3 |
| Relative Density. | 1.173g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 48 mg/mL (114.57 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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