Powder: -20°C for 3 years | In solvent: -80°C for 1 year
m-3M3FBS is a phospholipase C (PLC) activator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 68.00 | |
25 mg | In stock | $ 133.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 409.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | m-3M3FBS is a phospholipase C (PLC) activator. |
In vitro | m-3M3FBS stimulated a transient intracellular calcium concentration ([Ca(2+)](i)) increase in neutrophils.?Moreover, m-3M3FBS stimulated the formation of inositol phosphates in U937 cells, indicating that it stimulates PLC activity.?The compound showed no cell-type specificity in terms of [Ca(2+)](i) increase in the various cell lines including leukocytes, fibroblasts, and neuronal cells,?also ruled out the possible involvement of heterotrimeric G proteins in m-3M3FBS-stimulated signaling by confirming the following: 1) pertussis toxin does not inhibit m-3M3FBS-induced [Ca(2+)](i) increase;?2) m-3M3FBS does not stimulate cyclic AMP generation;?and 3) the inhibition of G(q) by the regulator of G protein-signaling 2 does not affect the m-3M3FBS-induced [Ca(2+)](i) increase.?m-3M3FBS stimulated PLC activity in vitro.?The purified isoforms of PLC that were tested (i.e., beta2, beta3, gamma1, gamma2, and delta1) were activated by m-3M3FBS and showed no isoform specificity[1]. |
Molecular Weight | 343.36 |
Formula | C16H16F3NO2S |
CAS No. | 200933-14-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.4 mg/mL (12.81 mM)
You can also refer to dose conversion for different animals. More
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m-3M3FBS 200933-14-8 Apoptosis Metabolism Phospholipase calcium superoxide cells THP-1 phosphate m 3M3FBS Inhibitor m3M3FBS leukemic U937 inositol inhibit neutrophils m-3M-3FBS inhibitor