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m-3M3FBS

Catalog No. T8531   CAS 200933-14-8

m-3M3FBS is a phospholipase C (PLC) activator.

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m-3M3FBS Chemical Structure
m-3M3FBS, CAS 200933-14-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 68.00
25 mg In stock $ 133.00
50 mg In stock $ 247.00
100 mg In stock $ 409.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.92%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description m-3M3FBS is a phospholipase C (PLC) activator.
In vitro m-3M3FBS stimulated a transient intracellular calcium concentration ([Ca(2+)](i)) increase in neutrophils.?Moreover, m-3M3FBS stimulated the formation of inositol phosphates in U937 cells, indicating that it stimulates PLC activity.?The compound showed no cell-type specificity in terms of [Ca(2+)](i) increase in the various cell lines including leukocytes, fibroblasts, and neuronal cells,?also ruled out the possible involvement of heterotrimeric G proteins in m-3M3FBS-stimulated signaling by confirming the following: 1) pertussis toxin does not inhibit m-3M3FBS-induced [Ca(2+)](i) increase;?2) m-3M3FBS does not stimulate cyclic AMP generation;?and 3) the inhibition of G(q) by the regulator of G protein-signaling 2 does not affect the m-3M3FBS-induced [Ca(2+)](i) increase.?m-3M3FBS stimulated PLC activity in vitro.?The purified isoforms of PLC that were tested (i.e., beta2, beta3, gamma1, gamma2, and delta1) were activated by m-3M3FBS and showed no isoform specificity[1].
Molecular Weight 343.36
Formula C16H16F3NO2S
CAS No. 200933-14-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.4 mg/mL (12.81 mM)

TargetMolReferences and Literature

1. Bae YS, et al. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63(5):1043-1050. 2. Lee YN, et al. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222(2):227-235.

Related compound libraries

This product is contained In the following compound libraries:
Lipid Metabolism Compound Library Hematonosis Compound Library Bioactive Compound Library Apoptosis Compound Library Bioactive Compounds Library Max Anti-Metabolism Disease Compound Library Anti-Obesity Compound Library Metabolism Compound Library NO PAINS Compound Library Wnt/Hedgehog/Notch Compound Library

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Keywords

m-3M3FBS 200933-14-8 Apoptosis Metabolism Phospholipase calcium superoxide cells THP-1 phosphate m 3M3FBS Inhibitor m3M3FBS leukemic U937 inositol inhibit neutrophils m-3M-3FBS inhibitor

 

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