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Palonosetron hydrochloride
Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
Catalog No. T1156Cas No. 135729-62-3
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Purity:99.92%
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Palonosetron hydrochloride
Catalog No. T1156Alias RS 25259 197, RS 25259, Palonosetron HClCas No. 135729-62-3
Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $47 | In Stock | |
| 50 mg | $55 | In Stock | |
| 100 mg | $86 | In Stock | |
| 200 mg | $135 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
| In vivo | Palonosetron exhibits a longer plasma half-life of approximately 40 hours compared to other antagonists in its class (ondansetron, 4 hours; tropisetron, 7.3 hours; dolasetron, 7.5 hours; ranisetron, 8.9 hours). Additionally, it demonstrates a hundredfold greater binding affinity to the 5-HT3 receptor, with a pKi of 10.5, which is significantly higher than that of granisetron (pKi 8.91), tropisetron (pKi 8.81), ondansetron (pKi 8.39), and dolasetron (pKi 7.6). |
| Alias | RS 25259 197, RS 25259, Palonosetron HCl |
| Molecular Weight | 332.87 |
| Formula | C19H24N2O·HCl |
| Cas No. | 135729-62-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 100 mg/mL (300.42 mM), Sonication is recommended. DMSO: 3.33 mg/mL (10.00 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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