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Pancuronium dibromide

🥰Excellent
Catalog No. T0166Cas No. 15500-66-0
Alias Pavulon, Pancuronium bromide

Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing with acetylcholine for receptor sites on the motor end-plate.

Pancuronium dibromide

Pancuronium dibromide

🥰Excellent
Purity: 99.27%
Catalog No. T0166Alias Pavulon, Pancuronium bromideCas No. 15500-66-0
Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing with acetylcholine for receptor sites on the motor end-plate.
Pack SizePriceAvailabilityQuantity
5 mg$32In Stock
10 mg$50In Stock
25 mg$75In Stock
50 mg$117In Stock
100 mg$198In Stock
200 mg$247In Stock
500 mg$415In Stock
1 mL x 10 mM (in DMSO)$57In Stock
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Purity:99.27%
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Product Introduction

Bioactivity
Description
Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing with acetylcholine for receptor sites on the motor end-plate.
Targets&IC50
AChR:5.5 nm
In vitro
Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. [1] Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria. [2] Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat.[3]
In vivo
Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dosedogs by 82%. Pancuroniumdecreases tidal volume (VT) and minute ventilation (VE) in low dosedogs by 40% and 55%. [4] Pancuronium limitscerebralhyperemia during prolongedseizuresby attenuating increases inbloodpressure as a result of elimination of skeletal muscle activity in newborn pigs. [5] Pancuroniumresults in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM intrachealsmooth musclestrips fromguinea-pigs.[6]
AliasPavulon, Pancuronium bromide
Chemical Properties
Molecular Weight732.67
FormulaC35H60Br2N2O4
Cas No.15500-66-0
Smiles[Br-].[Br-].[H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](OC(C)=O)[C@H](C[C@]12C)[N+]1(C)CCCCC1)[N+]1(C)CCCCC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 136.49 mM
DMSO: 60 mg/mL (81.89 mM)
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM1.3649 mL6.8244 mL13.6487 mL68.2435 mL
5 mM0.2730 mL1.3649 mL2.7297 mL13.6487 mL
10 mM0.1365 mL0.6824 mL1.3649 mL6.8244 mL
20 mM0.0682 mL0.3412 mL0.6824 mL3.4122 mL
50 mM0.0273 mL0.1365 mL0.2730 mL1.3649 mL
H2O
1mg5mg10mg50mg
100 mM0.0136 mL0.0682 mL0.1365 mL0.6824 mL

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