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Pheniramine maleate
🥰Excellent
Catalog No. T0370Cas No. 132-20-7
Alias Trimetose, Inhiston, Daneral
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide.
Pheniramine maleate
🥰Excellent
Purity: 99.79%
Catalog No. T0370Alias Trimetose, Inhiston, DaneralCas No. 132-20-7
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $30 | In Stock | |
| 50 mg | $38 | In Stock | |
| 100 mg | $50 | In Stock | |
| 200 mg | $60 | In Stock | |
| 500 mg | $93 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.79%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide. |
| In vivo | Pheniramine maleate binds to histamine H1 receptors, which inhibits the production of phospholipase A2 and the endothelium-derived relaxing factor NO. This leads to a reduction in the activation of guanylate cyclase due to NO deficiency, resulting in decreased levels of cyclic GMP (cGMP). Consequently, this suppresses the contraction of smooth muscle tissues, reduces capillary permeability, and diminishes histamine-induced allergic responses. |
| Alias | Trimetose, Inhiston, Daneral |
| Molecular Weight | 356.42 |
| Formula | C16H20N2·C4H4O4 |
| Cas No. | 132-20-7 |
| Smiles | CN(C)CCC(c1ccccc1)c1ccccn1.C(=C\C(=O)O)\C(=O)O |
| Relative Density. | 1.2233 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 65 mg/mL (182.4 mM) Ethanol: 66 mg/mL (185.2 mM) DMSO: 40 mg/mL (112.23 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O/Ethanol
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Tripotonspinal blocksedativeProphenpyridaminePheniramine MaleatePheniramine maleatePheniraminelumbar punctureJurkat ALLInhibitorinhibithypnotichuman T-cell acute lymphoblastic leukemiaHTHistamineReceptorHistamine Receptorfirst-generationCNScentral nervous systemCCRF-CEMCa2+ influxBC3H-1Apoptosisantipruriticantiemetic5HTReceptor5HT Receptor
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