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SC99

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Purity:99.68%

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COA HNMR HPLC

SC99

Catalog No. T8719Cas No. 882290-02-0

SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities

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Pack Size	Price	Availability
1 mg	$64	In Stock
5 mg	$156	In Stock
10 mg	$239	In Stock
25 mg	$423	In Stock
50 mg	$637	In Stock
100 mg	$793	In Stock
500 mg	$1,630	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock

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Product Introduction

Bioactivity

Description

In vitro

SC99 inhibited the phosphorylation of JAK2 and STAT3 in human platelets but had no effects on the phosphorylation of AKT, p65 or Src, all of which are involved in platelet activation.?SC99 inhibited human platelet aggregation induced by collagen and thrombin in a dose-dependent manner.?SC99 inhibited thrombin-induced P-selectin expression and fibrinogen binding to single platelets.?Moreover, SC99 inhibited platelet spreading on fibrinogen and clot retraction mediated by outside-in signaling.?SC99 inhibited platelet aggregation in mice but it did not significantly prolong the bleeding time.?SC99 inhibited platelet activation and aggregation as a STAT3 inhibitor.?This agent can be developed as a promising treatment for thrombotic disorders.

Chemical Properties

Molecular Weight	336.15
Formula	C15H8Cl2FN3O
Cas No.	882290-02-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 82 mg/mL (243.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9749 mL	14.8743 mL	29.7486 mL	148.7431 mL
5 mM	0.5950 mL	2.9749 mL	5.9497 mL	29.7486 mL
10 mM	0.2975 mL	1.4874 mL	2.9749 mL	14.8743 mL
20 mM	0.1487 mL	0.7437 mL	1.4874 mL	7.4372 mL
50 mM	0.0595 mL	0.2975 mL	0.5950 mL	2.9749 mL
100 mM	0.0297 mL	0.1487 mL	0.2975 mL	1.4874 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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