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T-1101 tosylate

T-1101 tosylate
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Purity:98.47%
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T-1101 tosylate

Catalog No. T8216Cas No. 2250404-95-4
T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 inhibitor with antitumor activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$74In Stock
5 mg$178In Stock
10 mg$289In Stock
25 mg$538In Stock
50 mg$778In Stock
100 mg$1,090In Stock
1 mL x 10 mM (in DMSO)$265In Stock
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Product Introduction

Bioactivity
Description
T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 inhibitor with antitumor activity.
In vitro
T-1101 has good oral absorption, along with potent in?vitro antiproliferative activity (IC50: 14.8-21.5?nM).
In vivo
T-1101 tosylate can achieve high concentrations in Huh-7 and MDA-MB-231 tumor tissues, and showed promise in antitumor activity in mice bearing human tumor xenografts of liver cancer (Huh-7).
Animal Research
SCID mice bearing human Huh-7, BT-474, MCF-7, and MDA-MB-231 xenografts. Dosage:25 mg/kg, 50 mg/kg. Oral administration; twice per day; 28 days
AliasTAI-95 tosylate
Chemical Properties
Molecular Weight665.8
FormulaC31H31N5O6S3
Cas No.2250404-95-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 11 mg/mL (16.52 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5020 mL7.5098 mL15.0195 mL75.0976 mL
5 mM0.3004 mL1.5020 mL3.0039 mL15.0195 mL
10 mM0.1502 mL0.7510 mL1.5020 mL7.5098 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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