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trifarotene

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Purity:99.78%

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COA HPLC HNMR

trifarotene

Catalog No. T7586Cas No. 895542-09-3

Trifarotene (CD5789) is a potent and selective RARγ agonist, exhibiting 65-fold and 16-fold selectivity for RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).

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Pack Size	Price	Availability
2 mg	$36	In Stock
5 mg	$58	In Stock
10 mg	$98	In Stock
25 mg	$163	In Stock
50 mg	$297	In Stock
100 mg	$496	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock

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Product Introduction

Bioactivity

Description	Trifarotene (CD5789) is a potent and selective RARγ agonist, exhibiting 65-fold and 16-fold selectivity for RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).
Targets&IC50	RARγ:7.7 nM (EC50), RARβ:125 nM (EC50), RARα:500 nM (EC50)
In vitro	Administration of trifarotene involves in keratinization, desquamation, cornification and cell adhesion in reconstructed human epidermis (RHE) with the mean EC50 on the combined target genes of 0.0048%[2].
In vivo	In rhino mice, administration of 0.001%-0.01% Trifarotene shows dose-dependent comedolytic activity. Being fully efficacious at 0.01% with reduction of 98%[2].
Alias	CD5789

Chemical Properties

Molecular Weight	459.58
Formula	C29H33NO4
Cas No.	895542-09-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 200 mg/mL (435.18 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1759 mL	10.8795 mL	21.7590 mL	108.7950 mL
5 mM	0.4352 mL	2.1759 mL	4.3518 mL	21.7590 mL
10 mM	0.2176 mL	1.0879 mL	2.1759 mL	10.8795 mL
20 mM	0.1088 mL	0.5440 mL	1.0879 mL	5.4397 mL
50 mM	0.0435 mL	0.2176 mL	0.4352 mL	2.1759 mL
100 mM	0.0218 mL	0.1088 mL	0.2176 mL	1.0879 mL

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