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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $36 | In Stock | |
5 mg | $58 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $163 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $496 | In Stock | |
1 mL x 10 mM (in DMSO) | $59 | In Stock |
Description | Trifarotene (CD5789) is a potent and selective RARγ agonist, exhibiting 65-fold and 16-fold selectivity for RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM). |
Targets&IC50 | RARγ:7.7 nM (EC50), RARβ:125 nM (EC50), RARα:500 nM (EC50) |
In vitro | Administration of trifarotene involves in keratinization, desquamation, cornification and cell adhesion in reconstructed human epidermis (RHE) with the mean EC50 on the combined target genes of 0.0048%[2]. |
In vivo | In rhino mice, administration of 0.001%-0.01% Trifarotene shows dose-dependent comedolytic activity. Being fully efficacious at 0.01% with reduction of 98%[2]. |
Alias | CD5789 |
Molecular Weight | 459.58 |
Formula | C29H33NO4 |
Cas No. | 895542-09-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/mL (435.18 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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