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trifarotene

Catalog No. T7586 CAS 895542-09-3

Synonyms: CD5789

Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).

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trifarotene, CAS 895542-09-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 556.00
1 mL * 10 mM (in DMSO)	In stock	$ 73.00

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Purity: 99.78%

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Description	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM).
Targets&IC50	RARβ:125 nM (EC50), RARγ:7.7 nM (EC50), RARα:500 nM (EC50)
In vitro	Administration of trifarotene involves in keratinization, desquamation, cornification and cell adhesion in reconstructed human epidermis (RHE) with the mean EC50 on the combined target genes of 0.0048%[2].
In vivo	In rhino mice, administration of 0.001%-0.01% Trifarotene shows dose-dependent comedolytic activity. Being fully efficacious at 0.01% with reduction of 98%[2].

Synonyms	CD5789
Molecular Weight	459.58
Formula	C29H33NO4
CAS No.	895542-09-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/ml(435.18 mM)

References and Literature

1. Etienne Thoreau, et al. Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1736-1741. 2. J Aubert, et al. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene. Br J Dermatol. 2018 Aug;179(2):442-456.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library EMA Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Bioactive Compound Library Reprogramming Compound Library Approved Drug Library Clinical Compound Library

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Keywords

trifarotene 895542-09-3 Autophagy Metabolism Retinoid Receptor RAR/RXR inhibit CD5789 CD 5789 RAR Retinoid X receptors acne CD-5789 Retinoic acid receptors Inhibitor selective inhibitor

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