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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | In Stock | |
5 mg | $243 | In Stock | |
10 mg | $405 | In Stock | |
25 mg | $676 | In Stock | |
50 mg | $962 | In Stock | |
100 mg | $1,280 | In Stock | |
1 mL x 10 mM (in DMSO) | $272 | In Stock |
Description | UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer. |
In vitro | In Hek-293 cells, UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202?nM after TNF (10?pM) stimulation. UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116?nM and a geometric mean IC50?of 120?nM, using human and mouse TNF, respectively. |
In vivo | UCB-9260 (150?mg/kg; p.o.) treatment twice daily?for 7 days shows a significant reduction of the clinical score. In adult male Balb/c mice, UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment. |
Molecular Weight | 423.51 |
Formula | C26H25N5O |
Cas No. | 1515888-53-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 4.23 mg/mL (10 mM) ![]() | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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