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ZSET1446

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Purity:99.32%

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COA HPLC LCMS HNMR

ZSET1446

Catalog No. T8448Cas No. 887603-94-3

ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.

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Pack Size	Price	Availability
1 mg	$80	In Stock
2 mg	$116	In Stock
5 mg	$183	In Stock
10 mg	$259	In Stock
25 mg	$522	In Stock
50 mg	$759	In Stock
100 mg	$1,060	In Stock
1 mL x 10 mM (in DMSO)	$213	In Stock

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Product Introduction

Bioactivity

Description	ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.
In vivo	ZSET1446 ameliorated cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test.?ZSET1446 also reduced grading scores of SAMP8 after 16 weeks of treatment.?Further, 8-week treatment of ZSET1446 significantly reduced the total number of Aβ-positive granules in the hippocampus.?ZSET1446 shows ameliorating effects on SAMP8 partly due to the suppression of an increase of Aβ-deposition in the hippocampus[1].
Animal Research	ZSET1446 was administered in drinking water at estimated doses of 0.002, 0.01, and 0.1 mg/kg per day from the age of 8 months mouse.?The SAMP8 at the age of 8 months showed cognitive impairment in a novel object recognition task compared with young SAMP8 at the age of 8 weeks.?Further, grading scores were gradually increased from 9 to 12 months and Aβ-like immunoreactivity in the hippocampus was increased at the age of 10 months[1].
Alias	ZSET-1446, ST-101

Chemical Properties

Molecular Weight	236.27
Formula	C15H12N2O
Cas No.	887603-94-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 29 mg/ml(122.74 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2324 mL	21.1622 mL	42.3245 mL	211.6223 mL
5 mM	0.8465 mL	4.2324 mL	8.4649 mL	42.3245 mL
10 mM	0.4232 mL	2.1162 mL	4.2324 mL	21.1622 mL
20 mM	0.2116 mL	1.0581 mL	2.1162 mL	10.5811 mL
50 mM	0.0846 mL	0.4232 mL	0.8465 mL	4.2324 mL
100 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1162 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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