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CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist with pEC50 values of 9.96 for human 5-HT2C, 7.19 for 5-HT2B, and 6.81 for 5-HT2A receptors.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
5 mg | $75 | In Stock | |
10 mg | $109 | In Stock | |
25 mg | $247 | In Stock | |
50 mg | $455 | In Stock | |
100 mg | $686 | In Stock |
Description | CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist with pEC50 values of 9.96 for human 5-HT2C, 7.19 for 5-HT2B, and 6.81 for 5-HT2A receptors. |
Targets&IC50 | 5-HT2B:7.19(pEC50 for human), 5-HT2C:9.96(pEC50 for human), 5-HT2A:6.81(pEC50 for human) |
In vitro | CP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro[4]. |
In vivo | Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively, and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test, and learned helplessness[4]. |
Molecular Weight | 341.24 |
Formula | C15H18Cl2N4O |
Cas No. | 1215721-40-6 |
Smiles | Cl.Clc1cccc(COc2cncc(n2)N2CCNCC2)c1 |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | H2O: 20 mg/mL (58.61 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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