Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 75.00 | |
25 mg | In stock | $ 126.00 | |
50 mg | In stock | $ 189.00 | |
100 mg | In stock | $ 278.00 | |
200 mg | In stock | $ 418.00 | |
500 mg | In stock | $ 682.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 83.00 |
Description | Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor. |
Targets&IC50 | Ca2+ channel, L-type:0.15 nM |
In vitro | Felodipine acts on the aortic wall by inhibiting NF-κB activation and effectively reduces serum insulin levels within macrophages, as well as intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), thereby significantly lowering systolic blood pressure and modulating vascular inflammatory responses. Oral administration of Felodipine in rats with 5/6 nephrectomy markedly decreases the mean arterial blood pressure. |
In vivo | In primary human VSMCs and lung fibroblasts, Felodipine significantly induced transcription and secretion of IL-6 (ED50: 5.8 nM) and IL-8 (ED50: 5.3 nM), with no effect observed from the administration of either propranolol or fenbufen on the expression of these IL genes. In guinea pig ileum longitudinal smooth muscle, Felodipine inhibited carbachol-regulated Ca2+-dependent contraction (IC50: 1.45 nM). At a concentration of 0.1 μM in rat endothelial cells, Felodipine increased NOx production and the activity of Ca2+-dependent NOS and eNOS proteins. At 10 μM, it suppressed human SMC proliferation by inhibiting PDGF-BB-induced Elk-1 activation and reducing the nuclear translocation of p42/44 mitogen-activated protein kinase. Felodipine moderately inhibited Cav3.2 T-type Ca2+ channels (IC50: 6.8 μM). In porcine coronary artery segments contracted with KCl, Felodipine significantly induced relaxation (IC50: 0.15 nM), suggesting it is 50 times more potent than nifedipine (IC50: ~8 nM) and 430 times more potent than verapamil (IC50: ~65 nM) due to its Ca2+ channel blocking action. |
Synonyms | CGH-869 |
Molecular Weight | 384.25 |
Formula | C18H19Cl2NO4 |
CAS No. | 72509-76-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38.4 mg/mL (100 mM)
Ethanol: 38.4 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Felodipine 72509-76-3 Autophagy Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor dihydropyridine smooth CGH 869 vascular inhibit CGH869 blood Ca2+ channels muscle pressure Ca channels L-type CGH-869 inhibitor