Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 30.00 | |
50 mg | In stock | $ 38.00 | |
100 mg | In stock | $ 57.00 | |
200 mg | In stock | $ 87.00 | |
500 mg | In stock | $ 197.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. |
In vitro | Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5'-O-mono amino acid ester prodrugs. [1] Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. [2] Floxuridine significantly inhibits the uptake of both [(3)H]-inosine and [(3)H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). [3] Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon's capsule fibroblasts in vitro. [4] Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction. [5] |
Synonyms | 5-Fluorouracil 2'-deoxyriboside, FUDR, Deoxyfluorouridine, NSC 27640 |
Molecular Weight | 246.19 |
Formula | C9H11FN2O5 |
CAS No. | 50-91-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 24.6 mg/mL (100 mM)
DMSO: 24.6 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Floxuridine 50-91-9 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Antibacterial HSV S. aureus cancer Ovarian Antimetabolite Herpes simplex virus CMV Inhibitor Oncology Cytomegalovirus 5-Fluorouracil 2'-deoxyriboside OVCAR-8 NSC27640 Bacterial SKOV3ip FUDR NSC-27640 Deoxyfluorouridine inhibit cells polymerase NSC 27640 inhibitor