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Orlistat
🥰Excellent
Catalog No. T0686Cas No. 96829-58-2
Alias Tetrahydrolipstatin, Ro-18-0647
Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a fatty acid synthase (FASN) inhibitor. Orlistat has been shown to promote weight loss.
Orlistat
🥰Excellent
Purity: 100%
Catalog No. T0686Alias Tetrahydrolipstatin, Ro-18-0647Cas No. 96829-58-2
Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a fatty acid synthase (FASN) inhibitor. Orlistat has been shown to promote weight loss.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | $52 | In Stock | |
| 200 mg | $81 | In Stock | |
| 500 mg | $133 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a fatty acid synthase (FASN) inhibitor. Orlistat has been shown to promote weight loss. |
| In vitro | METHODS: Prostate cancer cells PC3, DU145 and LNCaP were treated with Orlistat (10-300 µM) for 24 h and cell proliferation was detected by MTT assay. RESULTS: Increasing concentrations of Orlistat resulted in a dose-dependent decrease in cell viability of the three PCa cell lines tested. [1] METHODS: Breast cancer cells SK-Br3 were treated with Orlistat (40 µM) for 6-72 h. Cell cycle was measured by Flow cytometry. RESULTS: The time-dependent response of SK-Br3 breast cancer cells to Orlistat was characterized by the absence of G2-M populations and the accumulation of cells in the S phase of the cell cycle. Importantly, Orlistat exposure significantly promoted apoptosis, as evidenced by the time-dependent accumulation of sub-G1 populations with <2N DNA and representing dead cells. [2] |
| In vivo | METHODS: To detect anti-tumor activity in vivo, Orlistat (240 mg/kg, 33% ethanol and 66% PEG 400) was injected intraperitoneally into athymic nude mice bearing PC-3 xenografts once daily for three weeks. RESULTS: Orlistat prevented PC-3 tumor growth. In five separate experiments, tumor growth was blocked by 63%, 62%, 46%, 41%, and 16%. [3] |
| Alias | Tetrahydrolipstatin, Ro-18-0647 |
| Molecular Weight | 495.73 |
| Formula | C29H53NO5 |
| Cas No. | 96829-58-2 |
| Smiles | C([C@@H](OC([C@H](CC(C)C)NC=O)=O)CCCCCCCCCCC)[C@H]1[C@H](CCCCCC)C(=O)O1 |
| Relative Density. | 0.976 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (90.78 mM), Sonication is recommended.  Ethanol: 49.6 mg/mL (100.05 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 33% Ethanol + 67% PEG 400/PEG 300: 10 mg/mL (20.17 mM), In vivo: Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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