lipases

Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a fatty acid synthase (FASN) inhibitor. Orlistat has been shown to promote weight loss.

Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. It diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into cells in vivo, exhibiting potent proapoptotic, antiproliferative, and differentiation-inducing effects.

AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.

4-Nitrophenyl palmitate serves as a colorimetric substrate for lipase and esterase, enabling the quantification of enzyme activity through the release and colorimetric detection of 4-nitrophenol at 410 nm following enzymatic hydrolysis. This compound facilitates the characterization of enzyme activity across diverse bacterial and mammalian sources, including Burkholderia and porcine pancreatic lipases.

Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08 μg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells. Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function.

1-Palmitoyl-2-stearoyl-3-butyryl-rac-glycerol is a triacylglycerol that incorporates palmitic acid, stearic acid, and butyric acid at the sn-1, sn-2, and sn-3 positions, respectively. This compound serves as a substrate to establish the stereospecificity and typoselectivity of lipases.

1,3-Didecanoylglycerol is a saturated diacylglycerol with decanoic acid (Item No. 20838) at the sn-1 and sn-3 positions. It has been used in the formation of lipid monolayers in the study of lipases.

2-Hydroxy arachidic acid methyl ester, a hydroxylated fatty acid methyl ester identified in sediment samples from the Harney River and in petroleum ether extracts of I. eriocarpa, serves as a volatile flavoring compound in anhydrous milk fat (AMF). Its presence is diminished upon treatment with lipases lipozyme-435 and TL-IM in a time-dependent fashion. [Matreya, LLC. Catalog No. 1710]