Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 623.00 | |
5 mg | In stock | $ 995.00 | |
10 mg | In stock | $ 1,590.00 | |
25 mg | In stock | $ 2,350.00 | |
50 mg | In stock | $ 3,180.00 | |
100 mg | In stock | $ 4,290.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 987.00 |
Description | Pentiapine (CGS 10746) is a novel inhibitor of dopamine release. |
In vivo | Pentiapine effectively reduces motor activity in mice, both independently and in diminishing morphine-induced hyperactivity, on a dose-dependent basis. Analysis through Newman-Keuls post-hoc comparisons reveals that mice administered morphine and saline exhibit higher activity levels compared to those treated with incremental doses of 2 to 32 mg/kg of Pentiapine, with significant activity reductions observed at the 2 (P<0.05) and 32 (P<0.01) mg/kg levels. Additionally, lower doses of Pentiapine (0.5, 1, and 2 mg/kg) result in more activity than higher doses (4 to 32 mg/kg) in morphine-treated groups (P<0.01)[1]. A 30 mg/kg dose of Pentiapine completely inhibits the conditioned place preference (CPP) induced by methylenedioxymethamphetamine (MDMA) and prevents the establishment of a cocaine-induced CPP[2], demonstrating its potential in mitigating addictive behaviors. |
Synonyms | CGS 10746 |
Molecular Weight | 299.39 |
Formula | C15H17N5S |
CAS No. | 81382-51-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (317.31 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Pentiapine 81382-51-6 GPCR/G Protein Neuroscience Dopamine Receptor inhibit Inhibitor CGS 10746 CGS-10746 CGS10746 inhibitor