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R59949

Catalog No. T26019   CAS 120166-69-0
Synonyms: R-59949, R 59949

R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.

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R59949 Chemical Structure
R59949, CAS 120166-69-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 39.00
2 mg In stock $ 54.00
5 mg In stock $ 84.00
10 mg In stock $ 148.00
25 mg In stock $ 313.00
50 mg In stock $ 490.00
100 mg In stock $ 738.00
500 mg In stock $ 1,530.00
1 mL * 10 mM (in DMSO) In stock $ 105.00
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Purity: 98.82%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.
Synonyms R-59949, R 59949
Molecular Weight 489.58
Formula C28H25F2N3OS
CAS No. 120166-69-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (122.55 mM)

TargetMolReferences and Literature

1. Yang L, Xu Y, Li W, Yang B, Yu S, Zhou H, Yang C, Xu F, Wang J, Gao Y, Huang Y, Lu L, Liang X. Diacylglycerol kinase (DGK) inhibitor II (R59949) could suppress retinal neovascularization and protect retinal astrocytes in an oxygen-induced retinopathy model. J Mol Neurosci. 2015 May;56(1):78-88. doi: 10.1007/s12031-014-0469-2. Epub 2014 Dec 2. PubMed PMID: 25451596. 2. Tolan D, Conway AM, Pyne NJ, Pyne S. Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle. Am J Physiol. 1997 Sep;273(3 Pt 1):C928-36. PubMed PMID: 9316414. 3. Nakamura T, Kamishikiryo J, Morita T. Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II. Pharmacol Rep. 2016 Jun;68(3):649-53. doi: 10.1016/j.pharep.2016.02.001. Epub 2016 Feb 22. PubMed PMID: 27031052. 4. Torres-Ayuso P, Daza-Martín M, Martín-Pérez J, Ávila-Flores A, Mérida I. Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src. Oncotarget. 2014 Oct 30;5(20):9710-26. PubMed PMID: 25339152; PubMed Central PMCID: PMC4259432.

TargetMolCitations

1. Wu D, Wang J, Chang Y, et al.Rutaecarpin reduces lipids by DGKθ‐dependent activation of PPARα.Obesity.2022, 30(12): 2424-2439.

Related compound libraries

This product is contained In the following compound libraries:
TGF-beta/Smad Compound Library Bioactive Compounds Library Max Inhibitor Library Bioactive Compound Library Cytoskeletal Signaling Pathway Compound Library Kinase Inhibitor Library NO PAINS Compound Library Epigenetics Compound Library

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

R59949 120166-69-0 Chromatin/Epigenetic Cytoskeletal Signaling Others PKC kinase endogenous plasma platelet diacylglycerol Protein kinase C Inhibitor inhibit ligand membranes R-59949 R 59949 inhibitor

 

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