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Revefenacin

Catalog No. T7392 CAS 864750-70-9

Synonyms: TD-4208, GSK1160724

Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.

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Revefenacin, CAS 864750-70-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
2 mg	In stock	$ 72.00
5 mg	In stock	$ 105.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 328.00
50 mg	In stock	$ 487.00
100 mg	In stock	$ 696.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Purity: 96.66%

Biological Description

Chemical Properties

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Description	Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
Targets&IC50	M3 mAChR:0.18 Nm(ki)
In vivo	In anesthetized dogs, TD-4208, along with tiotropium and glycopyrronium, produced sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours. In anesthetized rats, inhaled TD-4208 exhibited dose-dependent 24-hour bronchoprotection against methacholine-induced bronchoconstriction. The estimated 24-hour potency (expressed as concentration of dosing solution) was 45.0 μg/ml[1].

Synonyms	TD-4208, GSK1160724
Molecular Weight	597.75
Formula	C35H43N5O4
CAS No.	864750-70-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (209.12 mM)

References and Literature

1. Pulido-Rios MT, McNamara A, Obedencio GP,et al.In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models[J].J Pharmacol Exp Ther. 2013 Aug;346(2):241-50. 2. Pudi KK, Barnes CN, Moran EJ,et al.A 28-day, randomized, double-blind, placebo-controlled, parallel group study of nebulized revefenacin in patients with chronic obstructive pulmonary disease[J].Respir Res. 2017 Nov 2;18(1):182.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Revefenacin 864750-70-9 Neuroscience AChR GSK 1160724 TD-4208 inhibit GSK1160724 Muscarinic acetylcholine receptor Inhibitor mAChR TD4208 TD 4208 GSK-1160724 inhibitor

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