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Simufilam dihydrochloride

Catalog No. T9172Cas No. 2480226-06-8
Alias PTI-125 dihydrochloride

Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.

Simufilam dihydrochloride

Simufilam dihydrochloride

Purity: 98.83%
Catalog No. T9172Alias PTI-125 dihydrochlorideCas No. 2480226-06-8
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
Pack SizePriceAvailabilityQuantity
1 mg$74In Stock
5 mg$153In Stock
10 mg$243In Stock
25 mg$515In Stock
50 mg$669In Stock
100 mg$871In Stock
200 mg$1,150In Stock
500 mg$1,680In Stock
1 mL x 10 mM (in DMSO)$173In Stock
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Purity:98.83%
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Product Introduction

Bioactivity
Description
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
In vitro
Simufilam dihydrochloride (1 pM~1 nM) increases NMDA/glycine-induced Arc expression in a dose-dependent manner. Simufilam dihydrochloride (1 nM, 1 hour) largely restores filamin A to its native conformation and effectively normalizes receptor activities in AD frontal cortices. Simufilam dihydrochloride dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam dihydrochloride reduces Ab42's binding affinity for a7nAChR, thereby prevents Ab42's signaling and further accumulation on a7nAChRs.
In vivo
Simufilam dihydrochloride (22 mg/kg; p.o.) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam dihydrochloride significantly improves spatial memory.
AliasPTI-125 dihydrochloride
Chemical Properties
Molecular Weight332.3
FormulaC15H23Cl2N3O
Cas No.2480226-06-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/ml (195.61 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0093 mL15.0466 mL30.0933 mL150.4664 mL
5 mM0.6019 mL3.0093 mL6.0187 mL30.0933 mL
10 mM0.3009 mL1.5047 mL3.0093 mL15.0466 mL
20 mM0.1505 mL0.7523 mL1.5047 mL7.5233 mL
50 mM0.0602 mL0.3009 mL0.6019 mL3.0093 mL
100 mM0.0301 mL0.1505 mL0.3009 mL1.5047 mL

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