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CAY10404

🥰Excellent
Catalog No. T8656Cas No. 340267-36-9
Alias 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cells, with analgesic, anti-inflammatory and anti-cancer activities.

CAY10404

CAY10404

🥰Excellent
Purity: 99.02%
Catalog No. T8656Alias 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-TCas No. 340267-36-9
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cells, with analgesic, anti-inflammatory and anti-cancer activities.
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$48In Stock
10 mg$88In Stock
25 mg$187In Stock
50 mg$319In Stock
100 mg$461In Stock
200 mg$648In Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Purity:99.02%
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Product Introduction

Bioactivity
Description
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cells, with analgesic, anti-inflammatory and anti-cancer activities.
Targets&IC50
COX-2:1 nM, COX-1:>500 μM
In vitro
Treatment with CAY10404 in the range of 10-100 microM caused dose-dependent growth inhibition, with an average 50% inhibitory concentration (IC(50)) of 60-100 micromol/L, depending on the cell line.?Western blot analysis of CAY10404-treated cells showed cleavage of poly (ADP-ribose) polymerase (PARP) and procaspase-3, signifying caspase activity and apoptotic cell death.?CAY10404 treatment inhibited the phosphorylation of Akt, glycogen synthase kinase-3beta and extracellular signal-regulated kinases 1/2 in H460 and H358 cells[1]
Cell Research
To measure the effects of CAY10404 on proliferation of NSCLC cells, 3 x 10(3) cells/well were plated in 96-well plates and allowed to adhere overnight at 37 degrees C. After treatment with CAY10404 for 3 days, cell proliferation was measured by the 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In the H460 NSCLC cells, evidence of apoptosis was sought using the terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labelling (TUNEL) assay and western blot analysis[1].
Alias3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T
Chemical Properties
Molecular Weight367.34
FormulaC17H12F3NO3S
Cas No.340267-36-9
SmilesCS(=O)(=O)c1ccc(cc1)-c1noc(c1-c1ccccc1)C(F)(F)F
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (27.22 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7223 mL13.6114 mL27.2227 mL136.1137 mL
5 mM0.5445 mL2.7223 mL5.4445 mL27.2227 mL
10 mM0.2722 mL1.3611 mL2.7223 mL13.6114 mL
20 mM0.1361 mL0.6806 mL1.3611 mL6.8057 mL

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