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Diclofensine hydrochloride
🥰Excellent
Catalog No. T7745Cas No. 34041-84-4
Alias Ro 8-4650 hydrochloride
Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a Novel Antidepressant, on Peripheral Adrenergic Function
Diclofensine hydrochloride
🥰Excellent
Purity: 99.93%
Catalog No. T7745Alias Ro 8-4650 hydrochlorideCas No. 34041-84-4
Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a Novel Antidepressant, on Peripheral Adrenergic Function
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 44 € | In Stock | |
| 10 mg | 73 € | In Stock | |
| 25 mg | 147 € | In Stock | |
| 50 mg | 282 € | In Stock | |
| 100 mg | 406 € | In Stock | |
| 200 mg | 568 € | In Stock |
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CitedSelect Batch
Purity:99.93%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a Novel Antidepressant, on Peripheral Adrenergic Function |
| In vitro | The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE).?The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake.?PE sensitivity was also enhanced by diclofensine as well as after a single dose of desmethylimipramine (DMI).?In contrast to the common opinion that PE does not interact with the neuronal uptake mechanism, the increase in PE-induced blood pressure response after diclofensine and DMI suggests that PE, a nonbiogenic amine, does indeed enter into the peripheral adrenergic neuron[1]. |
| Alias | Ro 8-4650 hydrochloride |
| Molecular Weight | 358.69 |
| Formula | C17H18Cl3NO |
| Cas No. | 34041-84-4 |
| Smiles | Cl.COc1ccc2C(CN(C)Cc2c1)c1ccc(Cl)c(Cl)c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 52 mg/mL (144.97 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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