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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $36 | In Stock | |
50 mg | $46 | In Stock | |
100 mg | $59 | In Stock | |
200 mg | $90 | In Stock | |
500 mg | $135 | In Stock | |
1 mL x 10 mM (in DMSO) | $48 | In Stock |
Description | Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. |
Targets&IC50 | mAChR (SHR-E):170.3 nM, mAChR (WKY-E):162.5 nM |
In vitro | Homatropine [14C]methylbromide administered rectally in rats achieved higher and quicker peak plasma concentrations compared to other routes. After 12 hours, 28% of the [14C] was excreted in the urine, with 56% remaining in the colon. Unlabeled homatropine methylbromide, delivered via a rectal suppository in anesthetized rats, rapidly blocked the effects of the vagus nerve on heart rate and of intravenous acetylcholine on blood pressure. A dose of 20 mg/kg homatropine increased the survival rate to 30% in rats poisoned with diazinon, with death occurring between 4 to 12 minutes, whereas a 10 mg/kg dose was ineffective in preventing mortality. |
In vivo | When combined with hexamethonium, 20 μM Homatropine yields only a dose ratio of 95.0 in guinea pig atria. In contrast, 20 μM Homatropine alone produces a dose ratio of 259 in guinea pig atria. |
Alias | Homatropine methobromide |
Molecular Weight | 370.29 |
Formula | C17H24BrNO3 |
Cas No. | 80-49-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (135.03 mM) ![]() Ethanol: 10 mg/mL (27.0 mM) H2O: 68 mg/mL (183.6 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO/H2O
DMSO/H2O
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