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Homatropine Methylbromide
Catalog No. T0427Cas No. 80-49-9
Alias Homatropine methobromide
Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
Homatropine Methylbromide
Catalog No. T0427Alias Homatropine methobromideCas No. 80-49-9
Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $36 | In Stock | |
| 50 mg | $46 | In Stock | |
| 100 mg | $59 | In Stock | |
| 200 mg | $90 | In Stock | |
| 500 mg | $135 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. |
| Targets&IC50 | mAChR (WKY-E):162.5 nM, mAChR (SHR-E):170.3 nM |
| In vitro | Homatropine [14C]methylbromide administered rectally in rats achieved higher and quicker peak plasma concentrations compared to other routes. After 12 hours, 28% of the [14C] was excreted in the urine, with 56% remaining in the colon. Unlabeled homatropine methylbromide, delivered via a rectal suppository in anesthetized rats, rapidly blocked the effects of the vagus nerve on heart rate and of intravenous acetylcholine on blood pressure. A dose of 20 mg/kg homatropine increased the survival rate to 30% in rats poisoned with diazinon, with death occurring between 4 to 12 minutes, whereas a 10 mg/kg dose was ineffective in preventing mortality. |
| In vivo | When combined with hexamethonium, 20 μM Homatropine yields only a dose ratio of 95.0 in guinea pig atria. In contrast, 20 μM Homatropine alone produces a dose ratio of 259 in guinea pig atria. |
| Alias | Homatropine methobromide |
| Molecular Weight | 370.29 |
| Formula | C17H24BrNO3 |
| Cas No. | 80-49-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (135.03 mM)  Ethanol: 10 mg/mL (27.0 mM) H2O: 68 mg/mL (183.6 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO/H2O
DMSO/H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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