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Homatropine Methylbromide

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Catalog No. T0427Cas No. 80-49-9
Alias Homatropine methobromide

Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.

Homatropine Methylbromide

Homatropine Methylbromide

🥰Excellent
Purity: 100%
Catalog No. T0427Alias Homatropine methobromideCas No. 80-49-9
Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
Pack SizePriceAvailabilityQuantity
25 mg$36In Stock
50 mg$46In Stock
100 mg$59In Stock
200 mg$90In Stock
500 mg$135In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.
Targets&IC50
mAChR (SHR-E):170.3 nM, mAChR (WKY-E):162.5 nM
In vitro
Homatropine [14C]methylbromide administered rectally in rats achieved higher and quicker peak plasma concentrations compared to other routes. After 12 hours, 28% of the [14C] was excreted in the urine, with 56% remaining in the colon. Unlabeled homatropine methylbromide, delivered via a rectal suppository in anesthetized rats, rapidly blocked the effects of the vagus nerve on heart rate and of intravenous acetylcholine on blood pressure. A dose of 20 mg/kg homatropine increased the survival rate to 30% in rats poisoned with diazinon, with death occurring between 4 to 12 minutes, whereas a 10 mg/kg dose was ineffective in preventing mortality.
In vivo
When combined with hexamethonium, 20 μM Homatropine yields only a dose ratio of 95.0 in guinea pig atria. In contrast, 20 μM Homatropine alone produces a dose ratio of 259 in guinea pig atria.
AliasHomatropine methobromide
Chemical Properties
Molecular Weight370.29
FormulaC17H24BrNO3
Cas No.80-49-9
Smiles[Br-].C[N+]1(C)[C@H]2CC[C@@H]1CC(C2)OC(=O)C(O)c1ccccc1
Relative Density.1.21g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (135.03 mM)
Ethanol: 10 mg/mL (27.0 mM)
H2O: 68 mg/mL (183.6 mM)
Solution Preparation Table
Ethanol/DMSO/H2O
1mg5mg10mg50mg
1 mM2.7006 mL13.5029 mL27.0059 mL135.0293 mL
5 mM0.5401 mL2.7006 mL5.4012 mL27.0059 mL
10 mM0.2701 mL1.3503 mL2.7006 mL13.5029 mL
20 mM0.1350 mL0.6751 mL1.3503 mL6.7515 mL
DMSO/H2O
1mg5mg10mg50mg
50 mM0.0540 mL0.2701 mL0.5401 mL2.7006 mL
100 mM0.0270 mL0.1350 mL0.2701 mL1.3503 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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