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JHU37152

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Purity:98.12%

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COA HPLC HNMR

JHU37152

Catalog No. T9019Cas No. 2369979-67-7

JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.

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Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$80	In Stock
10 mg	$139	In Stock
25 mg	$288	In Stock
50 mg	$448	In Stock
100 mg	$658	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Product Introduction

Bioactivity

Description	JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
In vitro	JHU 37152 is a potent DREADD agonist with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells
In vivo	JHU 37152 exhibits high in vivo DREADD potency. JHU37152 exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice
Alias	JHU 37152

Chemical Properties

Molecular Weight	358.84
Formula	C19H20ClFN4
Cas No.	2369979-67-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 72 mg/mL (200.65 mM)

Ethanol: 24 mg/mL (66.88 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.7868 mL	13.9338 mL	27.8676 mL	139.3379 mL
5 mM	0.5574 mL	2.7868 mL	5.5735 mL	27.8676 mL
10 mM	0.2787 mL	1.3934 mL	2.7868 mL	13.9338 mL
20 mM	0.1393 mL	0.6967 mL	1.3934 mL	6.9669 mL
50 mM	0.0557 mL	0.2787 mL	0.5574 mL	2.7868 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0279 mL	0.1393 mL	0.2787 mL	1.3934 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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