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L-741626
🥰Excellent
Catalog No. T15686Cas No. 81226-60-0
Alias 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).
L-741626
🥰Excellent
Purity: 98.57%
Catalog No. T15686Alias 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indoleCas No. 81226-60-0
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $30 | In Stock | |
| 10 mg | $48 | In Stock | |
| 25 mg | $94 | In Stock | |
| 50 mg | $173 | In Stock | |
| 100 mg | $278 | In Stock | |
| 200 mg | $397 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $31 | In Stock |
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CitedSelect Batch
Purity:98.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively). |
| Targets&IC50 | D2 receptor (human):(ki)2.4 nM, D4 receptor (human):220 nM(ki), D3 receptor (human):100 nM(ki) |
| In vitro | L-741626 is an effective antagonist (EC50 (D2)=4.46 nM) with some D2 selectivity (EC50 (D3)=90.4 nM), in the functional assay. L-741626 is prepared by literature methods (Ki (D2)=11.2 nM). L-741626 also shows a D3/D2 and D4/D2 selectivity ratio of 15-fold and 136-fold, respectively. Intrinsic activities using inhibition of quinpirole stimulation of mitogenesis in human dopamine D2 or D3 receptors transfected into Chinese hamster ovary (CHO) cells, in a functional assay [2]. |
| In vivo | In pramipexole-trained male Sprague Dawley rats, L-741626 (1.0 mg/kg; i.h.) is effective at shifting to the right the pramipexole dose-response curve [3]. Coadministration Cocaine with the D2 antagonist L-741626 (3 mg/kg; i.p.; 15 min before Cocaine) for 5 days decreases the Cocaine-induced enhance in microglial TNF-α production in adult mice [4]. |
| Alias | 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole |
| Molecular Weight | 340.85 |
| Formula | C20H21ClN2O |
| Cas No. | 81226-60-0 |
| Smiles | OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1 |
| Relative Density. | 1.311g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (117.35 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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