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nAChR agonist 1
Catalog No. T12165Cas No. 1394371-75-5
Alias DUN71755
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
nAChR agonist 1
Catalog No. T12165Alias DUN71755Cas No. 1394371-75-5
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $86 | In Stock | |
| 5 mg | $178 | In Stock | |
| 10 mg | $273 | In Stock | |
| 25 mg | $447 | In Stock | |
| 50 mg | $592 | In Stock | |
| 100 mg | $816 | In Stock | |
| 200 mg | $1,080 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $202 | In Stock |
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Purity:97.59%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. |
| In vivo | nAChR agonist 1(compound 28) is a novel PAM of α7 nicotinic acetylcholine receptor (α7 nAChR).?Compound 28 showed good in vitro potency, with pharmacokinetic profile across species with excellent brain penetration and residence time.?Compound 28 robustly reversed the cognitive deficits in episodic/working memory in both time-delay and scopolamine-induced amnesia paradigms in the novel object and social recognition tasks, at very low dose levels. |
| Alias | DUN71755 |
| Molecular Weight | 419.94 |
| Formula | C20H18ClNO3S2 |
| Cas No. | 1394371-75-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL (285.76 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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