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Nevanimibe hydrochloride
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM.
Catalog No. T12225LCas No. 133825-81-7
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Purity:99.25%
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Nevanimibe hydrochloride
Catalog No. T12225LCas No. 133825-81-7
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $87 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $463 | In Stock | |
| 50 mg | $592 | In Stock | |
| 100 mg | $787 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $235 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM. |
| Targets&IC50 | ACAT1:EC50 of 9 nM |
| In vitro | In H295R human adrenocortical carcinoma cells, Nevanimibe hydrochloride(ATR-101 hydrochloride) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity. Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis[2]. |
| Alias | PD-132301 hydrochloride, ATR101 hydrochloride |
| Molecular Weight | 458.08 |
| Formula | C27H40ClN3O |
| Cas No. | 133825-81-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 41.67 mg/mL (90.97 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
cancerO-acyltransferaseATR-101 Hydrochlorideacyl-CoA:cholesterol acyltransferasePD 132301 Hydrochlorideacyl-coenzymePD-132301Diglyceride acyltransferaseorallyadrenocorticalAcyltransferaseA:cholesterolmono- acylglycerol acyltransferaseNevanimibe hydrochlorideinhibitATR101 HydrochloridePD132301 HydrochlorideATR 101 HydrochloridePD 132301PD-132301 HydrochlorideNevanimibe HydrochlorideApoptosisNevanimibeATR 101PD132301ATR-101Diacylglycerol acyltransferaseactiveATR101Inhibitor
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