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Nevanimibe hydrochloride
🥰Excellent
Catalog No. T12225LCas No. 133825-81-7
Alias PD-132301 hydrochloride, ATR101 hydrochloride
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM.
Nevanimibe hydrochloride
🥰Excellent
Purity: 99.25%
Catalog No. T12225LAlias PD-132301 hydrochloride, ATR101 hydrochlorideCas No. 133825-81-7
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $87 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $463 | In Stock | |
| 50 mg | $592 | In Stock | |
| 100 mg | $787 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $235 | In Stock |
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Purity:99.25%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active, selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) with an EC50 of 9 nM. |
| Targets&IC50 | ACAT1:EC50 of 9 nM |
| In vitro | In H295R human adrenocortical carcinoma cells, Nevanimibe hydrochloride(ATR-101 hydrochloride) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity. Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis[2]. |
| Alias | PD-132301 hydrochloride, ATR101 hydrochloride |
| Molecular Weight | 458.08 |
| Formula | C27H40ClN3O |
| Cas No. | 133825-81-7 |
| Smiles | Cl.CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(CCCC1)c1ccc(cc1)N(C)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 41.67 mg/mL (90.97 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
PD-132301 HydrochloridePD132301 HydrochloridePD-132301PD132301PD 132301 HydrochloridePD 132301orallyO-acyltransferaseNevanimibe hydrochlorideNevanimibe HydrochlorideNevanimibemono- acylglycerol acyltransferaseInhibitorinhibitDiglyceride acyltransferaseDiacylglycerol acyltransferasecancerATR-101 HydrochlorideATR101 HydrochlorideATR-101ATR101ATR 101 HydrochlorideATR 101ApoptosisadrenocorticalAcyltransferaseacyl-coenzymeacyl-CoA:cholesterol acyltransferaseactiveA:cholesterol
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