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p-MPPI hydrochloride
p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects.
Catalog No. T16421Cas No. 220643-77-6
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Purity:99.95%
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p-MPPI hydrochloride
Catalog No. T16421Cas No. 220643-77-6
p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $85 | In Stock | |
| 25 mg | $148 | In Stock | |
| 50 mg | $247 | In Stock | |
| 100 mg | $391 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $91 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects. |
| In vivo | pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep.?Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture.?No overt behavioural change was produced by p-MPPI alone.?Thus, p-MPPI behaved as a true 5-HT(1A) antagonist. |
| Animal Research | Animal Model:Adult male Swiss Webster mice (aged 8-9 weeks). Dosage:0.5, 1.5, 4.5 mg/kg. Administration:i.p. |
| Molecular Weight | 578.87 |
| Formula | C25H28ClIN4O2 |
| Cas No. | 220643-77-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (47.51 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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