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p-MPPI hydrochloride

Catalog No. T16421Cas No. 220643-77-6

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects.

p-MPPI hydrochloride

p-MPPI hydrochloride

Purity: 99.95%
Catalog No. T16421Cas No. 220643-77-6
p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects.
Pack SizePriceAvailabilityQuantity
10 mg$85In Stock
25 mg$148In Stock
50 mg$247In Stock
100 mg$391In Stock
1 mL x 10 mM (in DMSO)$91In Stock
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Purity:99.95%
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Product Introduction

Bioactivity
Description
p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects.
In vivo
pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep.?Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture.?No overt behavioural change was produced by p-MPPI alone.?Thus, p-MPPI behaved as a true 5-HT(1A) antagonist.
Animal Research
Animal Model:Adult male Swiss Webster mice (aged 8-9 weeks). Dosage:0.5, 1.5, 4.5 mg/kg. Administration:i.p.
Chemical Properties
Molecular Weight578.87
FormulaC25H28ClIN4O2
Cas No.220643-77-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (47.51 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7275 mL8.6375 mL17.2750 mL86.3752 mL
5 mM0.3455 mL1.7275 mL3.4550 mL17.2750 mL
10 mM0.1728 mL0.8638 mL1.7275 mL8.6375 mL
20 mM0.0864 mL0.4319 mL0.8638 mL4.3188 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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