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p-MPPI hydrochloride

Catalog No. T16421 CAS 220643-77-6

p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.

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p-MPPI hydrochloride, CAS 220643-77-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 85.00
25 mg	In stock	$ 148.00
50 mg	In stock	$ 247.00
100 mg	In stock	$ 391.00
1 mL * 10 mM (in DMSO)	In stock	$ 91.00

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Purity: 99.25%

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Description	p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
In vivo	pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep.?Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture.?No overt behavioural change was produced by p-MPPI alone.?Thus, p-MPPI behaved as a true 5-HT(1A) antagonist.
Animal Research	Animal Model:Adult male Swiss Webster mice (aged 8-9 weeks). Dosage:0.5, 1.5, 4.5 mg/kg. Administration:i.p.

Molecular Weight	578.87
Formula	C25H28ClIN4O2
CAS No.	220643-77-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (47.51 mM)

References and Literature

1. Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7. 2. Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Membrane Protein-targeted Compound Library GPCR Compound Library Angiogenesis related Compound Library Bioactive Compound Library Neuronal Signaling Compound Library Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library

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Keywords

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