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p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $85 | In Stock | |
25 mg | $148 | In Stock | |
50 mg | $247 | In Stock | |
100 mg | $391 | In Stock | |
1 mL x 10 mM (in DMSO) | $91 | In Stock |
Description | p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects. |
In vivo | pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep.?Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture.?No overt behavioural change was produced by p-MPPI alone.?Thus, p-MPPI behaved as a true 5-HT(1A) antagonist. |
Animal Research | Animal Model:Adult male Swiss Webster mice (aged 8-9 weeks). Dosage:0.5, 1.5, 4.5 mg/kg. Administration:i.p. |
Molecular Weight | 578.87 |
Formula | C25H28ClIN4O2 |
Cas No. | 220643-77-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (47.51 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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